Cargando…

Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents

BACKGROUND: In-stent restenosis (ISR) is the major limitation of percutaneous coronary stenting procedure. The elements like nickel, chromate and molybdenum are known to cause contact allergy. Hypersensitivity reaction, against these metal ions, may be one of the reasons of ISR. Cobalt chromium coro...

Descripción completa

Detalles Bibliográficos
Autores principales: Aliağaoğlu, Cihangir, Turan, Hakan, Erden, İsmail, Albayrak, Hülya, Özhan, Hakan, Başar, Cengiz, Gürlevik, Zehra, Alçelik, Ayşegül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505773/
https://www.ncbi.nlm.nih.gov/pubmed/23197908
http://dx.doi.org/10.5021/ad.2012.24.4.426
_version_ 1782250806645358592
author Aliağaoğlu, Cihangir
Turan, Hakan
Erden, İsmail
Albayrak, Hülya
Özhan, Hakan
Başar, Cengiz
Gürlevik, Zehra
Alçelik, Ayşegül
author_facet Aliağaoğlu, Cihangir
Turan, Hakan
Erden, İsmail
Albayrak, Hülya
Özhan, Hakan
Başar, Cengiz
Gürlevik, Zehra
Alçelik, Ayşegül
author_sort Aliağaoğlu, Cihangir
collection PubMed
description BACKGROUND: In-stent restenosis (ISR) is the major limitation of percutaneous coronary stenting procedure. The elements like nickel, chromate and molybdenum are known to cause contact allergy. Hypersensitivity reaction, against these metal ions, may be one of the reasons of ISR. Cobalt chromium coronary stents, which are increasingly being used in percutaneous coronary interventions, have more nickel amount than the stainless steel stents. OBJECTIVE: We aimed to investigate the association between nickel hypersensitivity reaction and ISR in patients treated with cobalt chromium coronary stents. METHODS: Epicutaneous patch tests for nickel were applied to 31 patients who had undergone elective cobalt chromium coronary stent implantation and had ISR in control angiogram. Thirty patients, without ISR, were included as the control group. Patch test results and other clinical variables were compared. RESULTS: There was no statistically significant difference of the mean age, sex, body mass index, rate of hypercholesterolemia, diabetes, hypertension and smoking between the patients with and without ISR. All other lesion characteristics were similar in the 2 groups. According to the patch test results, 7 patients had nickel contact allergy. All of these patients were in the ISR group, which was statistically significant (p<0.006). CONCLUSION: Patients treated with cobalt chromium coronary stents and had ISR were found to have significantly more nickel allergy than the control group. Nickel allergy may play role in restenosis pathophysiology.
format Online
Article
Text
id pubmed-3505773
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Korean Dermatological Association; The Korean Society for Investigative Dermatology
record_format MEDLINE/PubMed
spelling pubmed-35057732012-11-29 Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents Aliağaoğlu, Cihangir Turan, Hakan Erden, İsmail Albayrak, Hülya Özhan, Hakan Başar, Cengiz Gürlevik, Zehra Alçelik, Ayşegül Ann Dermatol Original Article BACKGROUND: In-stent restenosis (ISR) is the major limitation of percutaneous coronary stenting procedure. The elements like nickel, chromate and molybdenum are known to cause contact allergy. Hypersensitivity reaction, against these metal ions, may be one of the reasons of ISR. Cobalt chromium coronary stents, which are increasingly being used in percutaneous coronary interventions, have more nickel amount than the stainless steel stents. OBJECTIVE: We aimed to investigate the association between nickel hypersensitivity reaction and ISR in patients treated with cobalt chromium coronary stents. METHODS: Epicutaneous patch tests for nickel were applied to 31 patients who had undergone elective cobalt chromium coronary stent implantation and had ISR in control angiogram. Thirty patients, without ISR, were included as the control group. Patch test results and other clinical variables were compared. RESULTS: There was no statistically significant difference of the mean age, sex, body mass index, rate of hypercholesterolemia, diabetes, hypertension and smoking between the patients with and without ISR. All other lesion characteristics were similar in the 2 groups. According to the patch test results, 7 patients had nickel contact allergy. All of these patients were in the ISR group, which was statistically significant (p<0.006). CONCLUSION: Patients treated with cobalt chromium coronary stents and had ISR were found to have significantly more nickel allergy than the control group. Nickel allergy may play role in restenosis pathophysiology. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012-11 2012-11-08 /pmc/articles/PMC3505773/ /pubmed/23197908 http://dx.doi.org/10.5021/ad.2012.24.4.426 Text en Copyright © 2012 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Aliağaoğlu, Cihangir
Turan, Hakan
Erden, İsmail
Albayrak, Hülya
Özhan, Hakan
Başar, Cengiz
Gürlevik, Zehra
Alçelik, Ayşegül
Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
title Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
title_full Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
title_fullStr Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
title_full_unstemmed Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
title_short Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents
title_sort relation of nickel allergy with in-stent restenosis in patients treated with cobalt chromium stents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505773/
https://www.ncbi.nlm.nih.gov/pubmed/23197908
http://dx.doi.org/10.5021/ad.2012.24.4.426
work_keys_str_mv AT aliagaoglucihangir relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT turanhakan relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT erdenismail relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT albayrakhulya relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT ozhanhakan relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT basarcengiz relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT gurlevikzehra relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents
AT alcelikaysegul relationofnickelallergywithinstentrestenosisinpatientstreatedwithcobaltchromiumstents