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MHC Class I Cross-Presentation by Dendritic Cells Counteracts Viral Immune Evasion

DCs very potently activate CD8(+) T cells specific for viral peptides bound to MHC class I molecules. However, many viruses have evolved immune evasion mechanisms, which inactivate infected DCs and might reduce priming of T cells. Then MHC class I cross-presentation of exogenous viral Ag by non-infe...

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Detalles Bibliográficos
Autores principales:	Nopora, Katrin, Bernhard, Caroline A., Ried, Christine, Castello, Alejandro A., Murphy, Kenneth M., Marconi, Peggy, Koszinowski, Ulrich, Brocker, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505839/ https://www.ncbi.nlm.nih.gov/pubmed/23189079 http://dx.doi.org/10.3389/fimmu.2012.00348

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