Cargando…

Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons

New concepts on potassium channel function in neuroinflammation suggest that they regulate mechanisms of microglial activation, including intracellular calcium homeostasis, morphological alterations, pro-inflammatory cytokine release, antigen presentation, and phagocytosis. Although little is known...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolga, Amalia M., Culmsee, Carsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505862/ https://www.ncbi.nlm.nih.gov/pubmed/23189056 http://dx.doi.org/10.3389/fphar.2012.00196

Ejemplares similares

K(Ca)2 and K(Ca)3 Channels in Learning and Memory Processes, and Neurodegeneration
por: Kuiper, Els F. E., et al.
Publicado: (2012)

SK channel activation is neuroprotective in conditions of enhanced ER–mitochondrial coupling
por: Honrath, Birgit, et al.
Publicado: (2018)

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons
por: Dolga, A M, et al.
Publicado: (2014)

SK-Channel Activation Alters Peripheral Metabolic Pathways in Mice, but Not Lipopolysaccharide-Induced Fever or Inflammation
por: Bredehöft, Janne, et al.
Publicado: (2022)

One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons
por: Honrath, Birgit, et al.
Publicado: (2018)

The Potassium SK Channel Activator NS309 Protects Against Experimental Traumatic Brain Injury Through Anti-Inflammatory and Immunomodulatory Mechanisms
por: Chen, Tao, et al.
Publicado: (2019)

Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors
por: Bugay, Vladislav, et al.
Publicado: (2020)

K(Ca)2 channels activation prevents [Ca(2+)](i) deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia
por: Dolga, A M, et al.
Publicado: (2011)

Activation of SK/K(Ca) Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits
por: Zhu, Jie, et al.
Publicado: (2019)

Ion Fluxes through K(Ca)2 (SK) and Ca(v)1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A(1) Receptor-Mediated Actions in Spontaneously Beating Rat Atria
por: Bragança, Bruno, et al.
Publicado: (2016)

2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels
por: Simó-Vicens, Rafel, et al.
Publicado: (2018)

The Ca(2+ )activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro
por: Schlichter, Lyanne C, et al.
Publicado: (2010)

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans
por: Krabbendam, Inge E., et al.
Publicado: (2020)

Glucose-regulated protein 75 determines ER–mitochondrial coupling and sensitivity to oxidative stress in neuronal cells
por: Honrath, Birgit, et al.
Publicado: (2017)

CaMKII regulation of cardiac K channels
por: Mustroph, Julian, et al.
Publicado: (2014)

The neuroprotective role of microglial cells against amyloid beta‐mediated toxicity in organotypic hippocampal slice cultures
por: Richter, Maren, et al.
Publicado: (2020)

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease
por: Matschke, Lina A., et al.
Publicado: (2022)

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
por: Neher, Jonas J., et al.
Publicado: (2012)

Small-Conductance Ca(2+)-Activated Potassium Type 2 Channels Regulate the Formation of Contextual Fear Memory
por: Murthy, Saravana R. K., et al.
Publicado: (2015)

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate(1)
por: Herrik, Kjartan F., et al.
Publicado: (2012)

Inhibition of K(Ca)2 and K(v)11.1 Channels in Pigs With Left Ventricular Dysfunction
por: Citerni, Carlotta, et al.
Publicado: (2020)

Neuronal Voltage Gated Potassium Channels May Modulate Nitric Oxide Synthesis in Corpus Cavernosum
por: Senbel, Amira M., et al.
Publicado: (2017)

The Trials and Tribulations of Structure Assisted Design of K(Ca) Channel Activators
por: Shim, Heesung, et al.
Publicado: (2019)

Voltage Sensor Inactivation in Potassium Channels
por: Bähring, Robert, et al.
Publicado: (2012)

Roles of the Drosophila SK Channel (dSK) in Courtship Memory
por: Abou Tayoun, Ahmad N., et al.
Publicado: (2012)

Impact of arrhythmogenic calmodulin variants on small conductance Ca(2+)‐activated K(+) (SK3) channels
por: Saljic, Arnela, et al.
Publicado: (2019)

Medication Review by Community Pharmacists for Type 2 Diabetes Patients in Routine Care: Results of the DIATHEM-Study
por: Schindler, Elisabeth, et al.
Publicado: (2020)

Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex
por: Criado-Marrero, Marangelie, et al.
Publicado: (2014)

Loop Diuretics Inhibit Ischemia-Induced Intracellular Ca(2+) Overload in Neurons via the Inhibition of Voltage-Gated Ca(2+) and Na(+) Channels
por: Katnik, Christopher, et al.
Publicado: (2021)

Coupling of SK channels, L-type Ca(2+) channels, and ryanodine receptors in cardiomyocytes
por: Zhang, Xiao-Dong, et al.
Publicado: (2018)

Functional interaction of Junctophilin 2 with small‐ conductance Ca(2+)‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes
por: Fan, H. K., et al.
Publicado: (2017)

Ultrasound Stimulation Modulates Voltage-Gated Potassium Currents Associated With Action Potential Shape in Hippocampal CA1 Pyramidal Neurons
por: Lin, Zhengrong, et al.
Publicado: (2019)

α(1)-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity
por: Gold, Maike, et al.
Publicado: (2014)

Long-Term Enhancement of NMDA Receptor Function in Inhibitory Neurons Preferentially Modulates Potassium Channels and Cell Adhesion Molecules
por: Xia, Dan, et al.
Publicado: (2022)

Cytoplasmic Domains and Voltage-Dependent Potassium Channel Gating
por: Barros, Francisco, et al.
Publicado: (2012)

Voltage-Dependent Gating of hERG Potassium Channels
por: Cheng, Yen May, et al.
Publicado: (2012)

Mechanism of Electromechanical Coupling in Voltage-Gated Potassium Channels
por: Blunck, Rikard, et al.
Publicado: (2012)

Stereoselective Inhibition of the hERG1 Potassium Channel
por: Grilo, Liliana Sintra, et al.
Publicado: (2010)

Pleiotropic Effects of Simvastatin on the Regulation of Potassium Channels in Monocytes
por: Wang, Shaoping, et al.
Publicado: (2020)

Ca(2+)-Sensitive Potassium Channels
por: Orfali, Razan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pmq6dheul51hvlgi1dd6fofp7p