Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients

This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5...

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Detalles Bibliográficos
Autores principales: Akın, Dilara Fatma, Sipahi, Kadir, Kayaalp, Tuğba, Eğin, Yonca, Taşdelen, Serpil, Kürekçi, Emin, Ezer, Üstün, Akar, Nejat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505918/
https://www.ncbi.nlm.nih.gov/pubmed/23198154
http://dx.doi.org/10.1155/2012/250432
Descripción
Sumario:This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5,1%) of the patients carried the PT 20210 G-A heterozygous mutation. Of the 135 patients, only three had thrombotic event, none of which had these two mutations, which is common in Turkish population. Our findings revealed a controversial compared to the previous reports, which needs further investigation.

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