Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients

This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5...

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Autores principales: Akın, Dilara Fatma, Sipahi, Kadir, Kayaalp, Tuğba, Eğin, Yonca, Taşdelen, Serpil, Kürekçi, Emin, Ezer, Üstün, Akar, Nejat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505918/
https://www.ncbi.nlm.nih.gov/pubmed/23198154
http://dx.doi.org/10.1155/2012/250432
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author Akın, Dilara Fatma
Sipahi, Kadir
Kayaalp, Tuğba
Eğin, Yonca
Taşdelen, Serpil
Kürekçi, Emin
Ezer, Üstün
Akar, Nejat
author_facet Akın, Dilara Fatma
Sipahi, Kadir
Kayaalp, Tuğba
Eğin, Yonca
Taşdelen, Serpil
Kürekçi, Emin
Ezer, Üstün
Akar, Nejat
author_sort Akın, Dilara Fatma
collection PubMed
description This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5,1%) of the patients carried the PT 20210 G-A heterozygous mutation. Of the 135 patients, only three had thrombotic event, none of which had these two mutations, which is common in Turkish population. Our findings revealed a controversial compared to the previous reports, which needs further investigation.
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spelling pubmed-35059182012-11-29 Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients Akın, Dilara Fatma Sipahi, Kadir Kayaalp, Tuğba Eğin, Yonca Taşdelen, Serpil Kürekçi, Emin Ezer, Üstün Akar, Nejat Leuk Res Treatment Research Article This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5,1%) of the patients carried the PT 20210 G-A heterozygous mutation. Of the 135 patients, only three had thrombotic event, none of which had these two mutations, which is common in Turkish population. Our findings revealed a controversial compared to the previous reports, which needs further investigation. Hindawi Publishing Corporation 2012 2012-02-16 /pmc/articles/PMC3505918/ /pubmed/23198154 http://dx.doi.org/10.1155/2012/250432 Text en Copyright © 2012 Dilara Fatma Akın et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Akın, Dilara Fatma
Sipahi, Kadir
Kayaalp, Tuğba
Eğin, Yonca
Taşdelen, Serpil
Kürekçi, Emin
Ezer, Üstün
Akar, Nejat
Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients
title Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients
title_full Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients
title_fullStr Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients
title_full_unstemmed Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients
title_short Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients
title_sort factor v leiden and prothrombin 20210a mutations among turkish pediatric leukemia patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505918/
https://www.ncbi.nlm.nih.gov/pubmed/23198154
http://dx.doi.org/10.1155/2012/250432
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