Identification of a Novel P190-Derived Breakpoint Peptide Suitable for Peptide Vaccine Therapeutic Approach in Ph+ Acute Lymphoblastic Leukemia Patients

Ph+ acute lymphoblastic leukemia (Ph+ ALL) is a high-risk acute leukemia with poor prognosis, in which the specific t(9;22)(q34;q11) translocation results in a chimeric bcr-abl (e1a2 breakpoint) and in a 190 KD protein (p190) with constitutive tyrosine kinase activity. The advent of first- and secon...

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Detalles Bibliográficos
Autores principales: Ippoliti, Micaela, Defina, Marzia, Gozzini, Antonella, Baratè, Claudia, Aprile, Lara, Pietrini, Alice, Gozzetti, Alessandro, Raspadori, Donatella, Lauria, Francesco, Bocchia, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505930/
https://www.ncbi.nlm.nih.gov/pubmed/23198152
http://dx.doi.org/10.1155/2012/150651

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