Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression

LacI/GalR transcription regulators have extensive, non-conserved interfaces between their regulatory domains and the 18 amino acids that serve as ‘linkers’ to their DNA-binding domains. These non-conserved interfaces might contribute to functional differences between paralogs. Previously, two chimer...

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Detalles Bibliográficos
Autores principales: Meinhardt, Sarah, Manley, Michael W., Becker, Nicole A., Hessman, Jacob A., Maher, L. James, Swint-Kruse, Liskin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505978/
https://www.ncbi.nlm.nih.gov/pubmed/22965134
http://dx.doi.org/10.1093/nar/gks806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505978/
https://www.ncbi.nlm.nih.gov/pubmed/22965134
http://dx.doi.org/10.1093/nar/gks806

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