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Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression
LacI/GalR transcription regulators have extensive, non-conserved interfaces between their regulatory domains and the 18 amino acids that serve as ‘linkers’ to their DNA-binding domains. These non-conserved interfaces might contribute to functional differences between paralogs. Previously, two chimer...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505978/ https://www.ncbi.nlm.nih.gov/pubmed/22965134 http://dx.doi.org/10.1093/nar/gks806 |