Cargando…

Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration

Recent studies have implicated glutamate neurotransmission as an important substrate for the extinction of conditioned behaviors, including responding for drug reinforcement. Positive allosteric modulation of the type-5 metabotropic glutamate receptor (mGluR5) in particular has emerged as a treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kufahl, Peter R., Hood, Lauren E., Nemirovsky, Natali E., Barabas, Piroska, Halstengard, Casey, Villa, Angel, Moore, Elisabeth, Watterson, Lucas R., Olive, M. Foster
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506114/ https://www.ncbi.nlm.nih.gov/pubmed/23189054 http://dx.doi.org/10.3389/fphar.2012.00194

Ejemplares similares

Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine
por: Kufahl, Peter R, et al.
Publicado: (2013)

Extinction-Dependent Alterations in Corticostriatal mGluR2/3 and mGluR7 Receptors following Chronic Methamphetamine Self-Administration in Rats
por: Schwendt, Marek, et al.
Publicado: (2012)

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders
por: Cleva, Richard M., et al.
Publicado: (2011)

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
por: Ayala, Jennifer E., et al.
Publicado: (2009)

Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving
por: Loweth, Jessica A., et al.
Publicado: (2013)

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
por: Gross, Kellie S., et al.
Publicado: (2016)

Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction
por: Sethna, Ferzin, et al.
Publicado: (2014)

Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training
por: Mao, Sheng-Chun, et al.
Publicado: (2013)

Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction
por: Zhu, Guoqi, et al.
Publicado: (2017)

Effect of mGluR2 Positive Allosteric Modulation on Frontostriatal Working Memory Activation in Schizophrenia
por: Wolf, Daniel H., et al.
Publicado: (2022)

Correction: Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training
por: Mao, Sheng-Chun, et al.
Publicado: (2013)

Retraction: Inhibition of Spontaneous Recovery of Fear by mGluR5 after Prolonged Extinction Training
Publicado: (2020)

Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning
por: Xu, Jian, et al.
Publicado: (2013)

Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration
por: Cleva, Richard M., et al.
Publicado: (2012)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Azam, Shofiul, et al.
Publicado: (2022)

Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5
por: Martinez, Luis A., et al.
Publicado: (2016)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
por: Huang, Leyi, et al.
Publicado: (2023)

Profiling the Structural Determinants of Aryl Benzamide Derivatives as Negative Allosteric Modulators of mGluR5 by In Silico Study
por: Zhao, Yujing, et al.
Publicado: (2020)

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR(7) Allosteric Agonist
por: Dickson, Louise, et al.
Publicado: (2023)

Regulatory system of mGluR group II in the nucleus accumbens for methamphetamine‐induced dopamine increase by the medial prefrontal cortex
por: Haddar, Meriem, et al.
Publicado: (2019)

Are AMPA Receptor Positive Allosteric Modulators Potential Pharmacotherapeutics for Addiction?
por: Watterson, Lucas R., et al.
Publicado: (2013)

Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs
por: Jiang, Ludi, et al.
Publicado: (2015)

Selective and interactive effects of D(2) receptor antagonism and positive allosteric mGluR4 modulation on waiting impulsivity
por: Isherwood, Sarah N., et al.
Publicado: (2017)

Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation
por: Chong, Chi Ho, et al.
Publicado: (2019)

mGluR5, CB1 and neuroprotection
por: Carvalho, Toniana G., et al.
Publicado: (2016)

PET imaging of mGluR5 in Alzheimer’s disease
por: Mecca, Adam P., et al.
Publicado: (2020)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
por: Zhou, Wen, et al.
Publicado: (2013)

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
por: Bratek - Gerej, Ewelina, et al.
Publicado: (2021)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Harbers, Maria, et al.
Publicado: (2022)

Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator
por: Lin, Chia-Wen, et al.
Publicado: (2014)

Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators
por: Isherwood, Sarah N., et al.
Publicado: (2018)

Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures
por: Gassó, Patricia, et al.
Publicado: (2023)

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
por: Wang, Hoau-Yan, et al.
Publicado: (2018)

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression
por: Wood, Christian M., et al.
Publicado: (2018)

mGluR-Dependent Synaptic Plasticity in Drug-Seeking
por: Bellone, Camilla, et al.
Publicado: (2012)

Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD
por: Klein, Matthew E., et al.
Publicado: (2015)

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors
por: Upreti, Chirag, et al.
Publicado: (2021)

The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia
por: Griebel, Guy, et al.
Publicado: (2016)

Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats
por: Lai, Chih-Chia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_84jqdkolqciu53vfc0poc148kn