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Usefulness of milnacipran in treating phantom limb pain
BACKGROUND: Amputation of an extremity often results in the sensation of a “phantom limb” where the patient feels that the limb that has been amputated is still present. This is frequently accompanied by “phantom limb pain”. We report here the use of milnacipran, a serotonin and norepinephrine reupt...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506153/ https://www.ncbi.nlm.nih.gov/pubmed/23185119 http://dx.doi.org/10.2147/NDT.S37431 |
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author | Nagoshi, Yasuhide Watanabe, Akira Inoue, Saiko Kuroda, Tomoki Nakamura, Mitsuo Matsumoto, Yoshitake Fukui, Kenji |
author_facet | Nagoshi, Yasuhide Watanabe, Akira Inoue, Saiko Kuroda, Tomoki Nakamura, Mitsuo Matsumoto, Yoshitake Fukui, Kenji |
author_sort | Nagoshi, Yasuhide |
collection | PubMed |
description | BACKGROUND: Amputation of an extremity often results in the sensation of a “phantom limb” where the patient feels that the limb that has been amputated is still present. This is frequently accompanied by “phantom limb pain”. We report here the use of milnacipran, a serotonin and norepinephrine reuptake inhibitor, to treat phantom limb pain after amputation of injured or diseased limbs in three patients. METHODS AND RESULTS: The severity of phantom pain before and during treatment was quantified using a visual analog scale. In one case, phantom limb pain responded partially to treatment with high doses of paroxetine, and then replacement with milnacipran further improved the pain relief and long-term full pain relief was achieved. In the two other cases, milnacipran was used as first-line treatment and phantom limb pain responded rapidly. CONCLUSION: These results suggest that milnacipran administration may be useful in phantom limb pain, possibly as a first-line treatment. |
format | Online Article Text |
id | pubmed-3506153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35061532012-11-26 Usefulness of milnacipran in treating phantom limb pain Nagoshi, Yasuhide Watanabe, Akira Inoue, Saiko Kuroda, Tomoki Nakamura, Mitsuo Matsumoto, Yoshitake Fukui, Kenji Neuropsychiatr Dis Treat Case Series BACKGROUND: Amputation of an extremity often results in the sensation of a “phantom limb” where the patient feels that the limb that has been amputated is still present. This is frequently accompanied by “phantom limb pain”. We report here the use of milnacipran, a serotonin and norepinephrine reuptake inhibitor, to treat phantom limb pain after amputation of injured or diseased limbs in three patients. METHODS AND RESULTS: The severity of phantom pain before and during treatment was quantified using a visual analog scale. In one case, phantom limb pain responded partially to treatment with high doses of paroxetine, and then replacement with milnacipran further improved the pain relief and long-term full pain relief was achieved. In the two other cases, milnacipran was used as first-line treatment and phantom limb pain responded rapidly. CONCLUSION: These results suggest that milnacipran administration may be useful in phantom limb pain, possibly as a first-line treatment. Dove Medical Press 2012 2012-11-20 /pmc/articles/PMC3506153/ /pubmed/23185119 http://dx.doi.org/10.2147/NDT.S37431 Text en © 2012 Nagoshi et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Case Series Nagoshi, Yasuhide Watanabe, Akira Inoue, Saiko Kuroda, Tomoki Nakamura, Mitsuo Matsumoto, Yoshitake Fukui, Kenji Usefulness of milnacipran in treating phantom limb pain |
title | Usefulness of milnacipran in treating phantom limb pain |
title_full | Usefulness of milnacipran in treating phantom limb pain |
title_fullStr | Usefulness of milnacipran in treating phantom limb pain |
title_full_unstemmed | Usefulness of milnacipran in treating phantom limb pain |
title_short | Usefulness of milnacipran in treating phantom limb pain |
title_sort | usefulness of milnacipran in treating phantom limb pain |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506153/ https://www.ncbi.nlm.nih.gov/pubmed/23185119 http://dx.doi.org/10.2147/NDT.S37431 |
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