Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia

Before 2008, HIV-1 subtype A was the predominant genetic variant in the Novosibirsk oblast of Russia as well as in most parts of this country. However, a rapid spread of the recombinant HIV-1 02_AG form has been reported in Novosibirsk since 2009. We have analyzed the genome of the 10.RU.6637 isolat...

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Detalles Bibliográficos
Autores principales: Baryshev, P. B., Bogachev, V. V., Gashnikova, N. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506197/
https://www.ncbi.nlm.nih.gov/pubmed/22903393
http://dx.doi.org/10.1007/s00705-012-1442-4
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author Baryshev, P. B.
Bogachev, V. V.
Gashnikova, N. M.
author_facet Baryshev, P. B.
Bogachev, V. V.
Gashnikova, N. M.
author_sort Baryshev, P. B.
collection PubMed
description Before 2008, HIV-1 subtype A was the predominant genetic variant in the Novosibirsk oblast of Russia as well as in most parts of this country. However, a rapid spread of the recombinant HIV-1 02_AG form has been reported in Novosibirsk since 2009. We have analyzed the genome of the 10.RU.6637 isolate, a HIV-1 02_AG recombinant form, which represents a monophyletic cluster of the HIV-1 variants widespread in this region. Phylogenetic analysis has shown that the Siberian 10.RU.6637 isolate displays the highest sequence identity to the HIV-1 subtype AG forms circulating in Uzbekistan. However, recombination analysis of 10.RU.6637 has demonstrated that this isolate is a recombinant form between HIV-1 subtype A and CRF02_AG, differing in its genetic structure from both the CRF02_AG reference sequences and the Central Asian variants of HIV-1 02_AG.
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spelling pubmed-35061972012-11-28 Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia Baryshev, P. B. Bogachev, V. V. Gashnikova, N. M. Arch Virol Original Article Before 2008, HIV-1 subtype A was the predominant genetic variant in the Novosibirsk oblast of Russia as well as in most parts of this country. However, a rapid spread of the recombinant HIV-1 02_AG form has been reported in Novosibirsk since 2009. We have analyzed the genome of the 10.RU.6637 isolate, a HIV-1 02_AG recombinant form, which represents a monophyletic cluster of the HIV-1 variants widespread in this region. Phylogenetic analysis has shown that the Siberian 10.RU.6637 isolate displays the highest sequence identity to the HIV-1 subtype AG forms circulating in Uzbekistan. However, recombination analysis of 10.RU.6637 has demonstrated that this isolate is a recombinant form between HIV-1 subtype A and CRF02_AG, differing in its genetic structure from both the CRF02_AG reference sequences and the Central Asian variants of HIV-1 02_AG. Springer Vienna 2012-08-19 2012 /pmc/articles/PMC3506197/ /pubmed/22903393 http://dx.doi.org/10.1007/s00705-012-1442-4 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Baryshev, P. B.
Bogachev, V. V.
Gashnikova, N. M.
Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
title Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
title_full Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
title_fullStr Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
title_full_unstemmed Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
title_short Genetic characterization of an isolate of HIV type 1 AG recombinant form circulating in Siberia, Russia
title_sort genetic characterization of an isolate of hiv type 1 ag recombinant form circulating in siberia, russia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506197/
https://www.ncbi.nlm.nih.gov/pubmed/22903393
http://dx.doi.org/10.1007/s00705-012-1442-4
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