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α-Glucosidase inhibitors and their use in clinical practice
Post-prandial hyperglycemia still remains a problem in the management of type 2 diabetes mellitus. Of all available anti-diabetic drugs, α-glucosidase inhibitors seem to be the most effective in reducing post-prandial hyperglycemia. We conducted a review analyzing the clinical efficacy and safety of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506243/ https://www.ncbi.nlm.nih.gov/pubmed/23185202 http://dx.doi.org/10.5114/aoms.2012.31621 |
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author | Derosa, Giuseppe Maffioli, Pamela |
author_facet | Derosa, Giuseppe Maffioli, Pamela |
author_sort | Derosa, Giuseppe |
collection | PubMed |
description | Post-prandial hyperglycemia still remains a problem in the management of type 2 diabetes mellitus. Of all available anti-diabetic drugs, α-glucosidase inhibitors seem to be the most effective in reducing post-prandial hyperglycemia. We conducted a review analyzing the clinical efficacy and safety of α-glucosidase inhibitors, both alone and in combination with other anti-diabetic drugs, with respect to glycemic control, inflammation and atherosclerosis. α-Glucosidase inhibitors proved to be effective and safe both in monotherapy and as an add-on to other anti-diabetic drugs. Compared to miglitol and voglibose, acarbose seems to have some additive effects such as stabling carotid plaques, and reducing inflammation. Acarbose also proved to reverse impaired glucose tolerance to normal glucose tolerance. |
format | Online Article Text |
id | pubmed-3506243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-35062432012-11-26 α-Glucosidase inhibitors and their use in clinical practice Derosa, Giuseppe Maffioli, Pamela Arch Med Sci Mini-Special Issue paper: Management of diabetic patients with hypoglycemic agents Post-prandial hyperglycemia still remains a problem in the management of type 2 diabetes mellitus. Of all available anti-diabetic drugs, α-glucosidase inhibitors seem to be the most effective in reducing post-prandial hyperglycemia. We conducted a review analyzing the clinical efficacy and safety of α-glucosidase inhibitors, both alone and in combination with other anti-diabetic drugs, with respect to glycemic control, inflammation and atherosclerosis. α-Glucosidase inhibitors proved to be effective and safe both in monotherapy and as an add-on to other anti-diabetic drugs. Compared to miglitol and voglibose, acarbose seems to have some additive effects such as stabling carotid plaques, and reducing inflammation. Acarbose also proved to reverse impaired glucose tolerance to normal glucose tolerance. Termedia Publishing House 2012-11-07 2012-11-09 /pmc/articles/PMC3506243/ /pubmed/23185202 http://dx.doi.org/10.5114/aoms.2012.31621 Text en Copyright © 2012 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Mini-Special Issue paper: Management of diabetic patients with hypoglycemic agents Derosa, Giuseppe Maffioli, Pamela α-Glucosidase inhibitors and their use in clinical practice |
title | α-Glucosidase inhibitors and their use in clinical practice |
title_full | α-Glucosidase inhibitors and their use in clinical practice |
title_fullStr | α-Glucosidase inhibitors and their use in clinical practice |
title_full_unstemmed | α-Glucosidase inhibitors and their use in clinical practice |
title_short | α-Glucosidase inhibitors and their use in clinical practice |
title_sort | α-glucosidase inhibitors and their use in clinical practice |
topic | Mini-Special Issue paper: Management of diabetic patients with hypoglycemic agents |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506243/ https://www.ncbi.nlm.nih.gov/pubmed/23185202 http://dx.doi.org/10.5114/aoms.2012.31621 |
work_keys_str_mv | AT derosagiuseppe aglucosidaseinhibitorsandtheiruseinclinicalpractice AT maffiolipamela aglucosidaseinhibitorsandtheiruseinclinicalpractice |