Tropheryma whipplei aortic valve endocarditis, cured without surgical treatment

BACKGROUND: Culture-negative endocarditis due to Tropheryma whipplei is a rare disease. Mostly the diagnosis is made by histologic examination of resected heart valve tissue. CASE PRESENTATION: In this case report, we described a patient with a classical Whipple’s disease. Transesophageal echocardio...

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Detalles Bibliográficos
Autores principales: Algin, Ahmet, Wegdam-Blans, Marjolijn, Verduin, Kees, Janssen, Hans, van Dantzig, Jan-Melle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506451/
https://www.ncbi.nlm.nih.gov/pubmed/23110725
http://dx.doi.org/10.1186/1756-0500-5-600
Descripción
Sumario:BACKGROUND: Culture-negative endocarditis due to Tropheryma whipplei is a rare disease. Mostly the diagnosis is made by histologic examination of resected heart valve tissue. CASE PRESENTATION: In this case report, we described a patient with a classical Whipple’s disease. Transesophageal echocardiography (TEE) showed a vegetation on noncoronary cusp of the aortic valve. Whipple’s disease was confirmed by positive Tropheryma whipplei polymerase chain reaction (PCR) in EDTA blood and a duodenal biopsy with positive periodic acid-Schiff stain (PAS) macrophages. CONCLUSION: Due to timely diagnosis, our patient was treated with antibiotics without valve replacement.

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