GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn’s Disease Model

OBJECTIVES: Glucagon-like peptide 2 (GLP2) is an intestinal growth factor that has been shown to stimulate intestinal growth and reduce disease severity in preclinical models of short bowel syndrome and inflammatory bowel disease. Teduglutide, a recombinant human GLP2 variant (GLP2-2G), has increase...

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Detalles Bibliográficos
Autores principales: Alters, Susan E., McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506575/
https://www.ncbi.nlm.nih.gov/pubmed/23189208
http://dx.doi.org/10.1371/journal.pone.0050630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506575/
https://www.ncbi.nlm.nih.gov/pubmed/23189208
http://dx.doi.org/10.1371/journal.pone.0050630

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