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Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP

Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium ex...

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Detalles Bibliográficos
Autores principales:	White, Mark A., Li, Sheng, Tsalkova, Tamara, Mei, Fang C., Liu, Tong, Woods, Virgil L., Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506601/ https://www.ncbi.nlm.nih.gov/pubmed/23189173 http://dx.doi.org/10.1371/journal.pone.0049932

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