NADP(+) Binding to the Regulatory Subunit of Methionine Adenosyltransferase II Increases Intersubunit Binding Affinity in the Hetero-Trimer

Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates. Binding of regulatory β subunits and catalytic α2 dimers is known to increase the affinity for methionine, although...

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Detalles Bibliográficos
Autores principales: González, Beatriz, Garrido, Francisco, Ortega, Rebeca, Martínez-Júlvez, Marta, Revilla-Guarinos, Ainhoa, Pérez-Pertejo, Yolanda, Velázquez-Campoy, Adrián, Sanz-Aparicio, Julia, Pajares, María A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506619/
https://www.ncbi.nlm.nih.gov/pubmed/23189196
http://dx.doi.org/10.1371/journal.pone.0050329

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