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Pharmacological Activation of the Bile Acid Nuclear Farnesoid X Receptor Is Feasible in Patients with Quiescent Crohn's Colitis

BACKGROUND: The bile acid-activated nuclear receptor Farnesoid X Receptor (FXR) is critical in maintaining intestinal barrier integrity and preventing bacterial overgrowth. Patients with Crohn's colitis (CC) exhibit reduced ileal FXR target gene expression. FXR agonists have been shown to ameli...

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Detalles Bibliográficos
Autores principales:	van Schaik, Fiona D. M., Gadaleta, Raffaella M., Schaap, Frank G., van Mil, Saskia W. C., Siersema, Peter D., Oldenburg, Bas, van Erpecum, Karel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506649/ https://www.ncbi.nlm.nih.gov/pubmed/23189156 http://dx.doi.org/10.1371/journal.pone.0049706

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