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The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas
Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506916/ https://www.ncbi.nlm.nih.gov/pubmed/23213624 http://dx.doi.org/10.1155/2012/913523 |
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author | Raess, Philipp W. Bagg, Adam |
author_facet | Raess, Philipp W. Bagg, Adam |
author_sort | Raess, Philipp W. |
collection | PubMed |
description | Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, as well as a comparison of various current protocols. The pitfalls and limitations of ARGR analysis are also highlighted. Recent advances in the understanding of the molecular pathogenesis of various cutaneous lymphomas are discussed. Some of these nascent discoveries may lead to the development of diagnostically useful molecular assays. |
format | Online Article Text |
id | pubmed-3506916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35069162012-12-04 The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas Raess, Philipp W. Bagg, Adam Patholog Res Int Review Article Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, as well as a comparison of various current protocols. The pitfalls and limitations of ARGR analysis are also highlighted. Recent advances in the understanding of the molecular pathogenesis of various cutaneous lymphomas are discussed. Some of these nascent discoveries may lead to the development of diagnostically useful molecular assays. Hindawi Publishing Corporation 2012 2012-11-19 /pmc/articles/PMC3506916/ /pubmed/23213624 http://dx.doi.org/10.1155/2012/913523 Text en Copyright © 2012 P. W. Raess and A. Bagg. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Raess, Philipp W. Bagg, Adam The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas |
title | The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas |
title_full | The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas |
title_fullStr | The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas |
title_full_unstemmed | The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas |
title_short | The Role of Molecular Pathology in the Diagnosis of Cutaneous Lymphomas |
title_sort | role of molecular pathology in the diagnosis of cutaneous lymphomas |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506916/ https://www.ncbi.nlm.nih.gov/pubmed/23213624 http://dx.doi.org/10.1155/2012/913523 |
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