Cargando…

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains

INTRODUCTION: A hallmark of Alzheimer's disease (AD) is the presence of senile plaques composed of aggregated amyloid β (Aβ) peptides. Pathological aging (PA) is a postmortem classification that has been used to describe brains with plaque pathology similar in extent to AD, minimal cortical tau...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moore, Brenda D, Chakrabarty, Paramita, Levites, Yona, Kukar, Tom L, Baine, Ann-Marie, Moroni, Tina, Ladd, Thomas B, Das, Pritam, Dickson, Dennis W, Golde, Todd E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506932/ https://www.ncbi.nlm.nih.gov/pubmed/22621179 http://dx.doi.org/10.1186/alzrt121

Ejemplares similares

Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy
por: Das, Pritam, et al.
Publicado: (2006)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
por: Das, Pritam, et al.
Publicado: (2012)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies
por: Croft, Cara L., et al.
Publicado: (2019)

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
por: Golde, Todd E, et al.
Publicado: (2013)

Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis
por: Xu, Guilian, et al.
Publicado: (2020)

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
por: Chakrabarty, Paramita, et al.
Publicado: (2011)

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
por: Chakrabarty, Paramita, et al.
Publicado: (2012)

Designing antibodies against LRRK2-targeted tau epitopes
por: Hamm, Matthew, et al.
Publicado: (2018)

Intracerebral but Not Peripheral Infection of Live Porphyromonas gingivalis Exacerbates Alzheimer’s Disease Like Amyloid Pathology in APP-TgCRND8 Mice
por: Aravindraja, Chairmandurai, et al.
Publicado: (2022)

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
por: McFarland, Karen N, et al.
Publicado: (2021)

Short Aβ peptides attenuate Aβ42 toxicity in vivo
por: Moore, Brenda D., et al.
Publicado: (2018)

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice
por: Prasad, Tuhina, et al.
Publicado: (2017)

Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy
por: Levites, Yona, et al.
Publicado: (2021)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease
por: Li, Hong‐Dong, et al.
Publicado: (2021)

Normal cognition in transgenic BRI2-Aβ mice
por: Kim, Jungsu, et al.
Publicado: (2013)

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
por: Chakrabarty, Paramita, et al.
Publicado: (2013)

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
por: Verbeeck, Christophe, et al.
Publicado: (2012)

Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis
por: Hanna, Amanda, et al.
Publicado: (2012)

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
por: Dhillon, Jess-Karan S., et al.
Publicado: (2017)

Free-water imaging of the hippocampus is a sensitive marker of Alzheimer's disease
por: Ofori, Edward, et al.
Publicado: (2019)

Fyn depletion ameliorates tau(P301L)-induced neuropathology
por: Liu, Guanghao, et al.
Publicado: (2020)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes
por: Futch, Hunter S., et al.
Publicado: (2019)

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy
por: Clippinger, Amy K., et al.
Publicado: (2013)

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes
por: Goodwin, Marshall S., et al.
Publicado: (2021)

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model
por: Marino, Marika, et al.
Publicado: (2022)

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease
por: Chakrabarty, Paramita, et al.
Publicado: (2018)

Il-10 signaling reduces survival in mouse models of synucleinopathy
por: Cockey, Samuel G., et al.
Publicado: (2021)

Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease
por: Golde, Todd E, et al.
Publicado: (2013)

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
por: Magno, Lorenza, et al.
Publicado: (2019)

A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies
por: Moore, Brenda D., et al.
Publicado: (2023)

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease
por: Williams, Tosha, et al.
Publicado: (2020)

Open questions for Alzheimer’s disease immunotherapy
por: Golde, Todd E
Publicado: (2014)

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
por: Attems, Johannes, et al.
Publicado: (2014)

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
por: Ceballos-Diaz, Carolina, et al.
Publicado: (2015)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
por: Jung, Joo In, et al.
Publicado: (2014)

TDP-43 Pathology in Alzheimer’s Disease
por: Meneses, Axel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pu0v3lpll4eia1p7500m28rtj1