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Ayurvedic medicinal plants for Alzheimer's disease: a review

Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. No cure for Alzheimer's exists, and the drugs currently available to treat...

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Autores principales: Rao, Rammohan V, Descamps, Olivier, John, Varghese, Bredesen, Dale E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506936/
https://www.ncbi.nlm.nih.gov/pubmed/22747839
http://dx.doi.org/10.1186/alzrt125
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author Rao, Rammohan V
Descamps, Olivier
John, Varghese
Bredesen, Dale E
author_facet Rao, Rammohan V
Descamps, Olivier
John, Varghese
Bredesen, Dale E
author_sort Rao, Rammohan V
collection PubMed
description Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. No cure for Alzheimer's exists, and the drugs currently available to treat the disease have limited effectiveness. It is believed that therapeutic intervention that could postpone the onset or progression of Alzheimer's disease would dramatically reduce the number of cases in the next 50 years. Ayurvedic medicinal plants have been the single most productive source of leads for the development of drugs, and over a hundred new products are already in clinical development. Indeed, several scientific studies have described the use of various Ayurvedic medicinal plants and their constituents for treatment of Alzheimer's disease. Although the exact mechanism of their action is still not clear, phytochemical studies of the different parts of the plants have shown the presence of many valuable compounds, such as lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, that show a wide spectrum of pharmacological activities, including anti-inflammatory, anti-amyloidogenic, anti-cholinesterase, hypolipidemic, and antioxidant effects. This review gathers research on various medicinal plants that have shown promise in reversing the Alzheimer's disease pathology. The report summarizes information concerning the phytochemistry, biological, and cellular activities and clinical applications of these various plants in order to provide sufficient baseline information that could be used in drug discovery campaigns and development process, thereby providing new functional leads for Alzheimer's disease.
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spelling pubmed-35069362012-12-29 Ayurvedic medicinal plants for Alzheimer's disease: a review Rao, Rammohan V Descamps, Olivier John, Varghese Bredesen, Dale E Alzheimers Res Ther Review Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. No cure for Alzheimer's exists, and the drugs currently available to treat the disease have limited effectiveness. It is believed that therapeutic intervention that could postpone the onset or progression of Alzheimer's disease would dramatically reduce the number of cases in the next 50 years. Ayurvedic medicinal plants have been the single most productive source of leads for the development of drugs, and over a hundred new products are already in clinical development. Indeed, several scientific studies have described the use of various Ayurvedic medicinal plants and their constituents for treatment of Alzheimer's disease. Although the exact mechanism of their action is still not clear, phytochemical studies of the different parts of the plants have shown the presence of many valuable compounds, such as lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, that show a wide spectrum of pharmacological activities, including anti-inflammatory, anti-amyloidogenic, anti-cholinesterase, hypolipidemic, and antioxidant effects. This review gathers research on various medicinal plants that have shown promise in reversing the Alzheimer's disease pathology. The report summarizes information concerning the phytochemistry, biological, and cellular activities and clinical applications of these various plants in order to provide sufficient baseline information that could be used in drug discovery campaigns and development process, thereby providing new functional leads for Alzheimer's disease. BioMed Central 2012-06-29 /pmc/articles/PMC3506936/ /pubmed/22747839 http://dx.doi.org/10.1186/alzrt125 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Review
Rao, Rammohan V
Descamps, Olivier
John, Varghese
Bredesen, Dale E
Ayurvedic medicinal plants for Alzheimer's disease: a review
title Ayurvedic medicinal plants for Alzheimer's disease: a review
title_full Ayurvedic medicinal plants for Alzheimer's disease: a review
title_fullStr Ayurvedic medicinal plants for Alzheimer's disease: a review
title_full_unstemmed Ayurvedic medicinal plants for Alzheimer's disease: a review
title_short Ayurvedic medicinal plants for Alzheimer's disease: a review
title_sort ayurvedic medicinal plants for alzheimer's disease: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506936/
https://www.ncbi.nlm.nih.gov/pubmed/22747839
http://dx.doi.org/10.1186/alzrt125
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