Cargando…

Digitoxin and its analogs as novel cancer therapeutics

A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elbaz, Hosam A, Stueckle, Todd A, Tse, William, Rojanasakul, Yon, Dinu, Cerasela Zoica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506989/ https://www.ncbi.nlm.nih.gov/pubmed/23210930 http://dx.doi.org/10.1186/2162-3619-1-4

Ejemplares similares

Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells
por: Lohcharoenkal, Warangkana, et al.
Publicado: (2014)

Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
por: Wagner, Alixandra, et al.
Publicado: (2018)

Induction of cancer-associated fibroblast-like cells by carbon nanotubes dictates its tumorigenicity
por: Luanpitpong, Sudjit, et al.
Publicado: (2016)

SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells
por: Voronkova, Maria A., et al.
Publicado: (2017)

Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells
por: Wagner, Alixandra, et al.
Publicado: (2019)

Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells
por: He, Xiaoqing, et al.
Publicado: (2017)

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis
por: Manke, Amruta, et al.
Publicado: (2014)

Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis
por: Luanpitpong, Sudjit, et al.
Publicado: (2014)

Digitoxin—A Critical Review
por: Diefenbach, William C., et al.
Publicado: (1949)

A bio-pen for direct writing of single molecules on user-functionalized surfaces
por: Hu, Xiao, et al.
Publicado: (2019)

Current status and perspectives in atomic force microscopy-based identification of cellular transformation
por: Dong, Chenbo, et al.
Publicado: (2016)

Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel
por: YAKISICH, JUAN SEBASTIAN, et al.
Publicado: (2016)

Hyaluronic Acid Allows Enzyme Immobilization for Applications in Biomedicine
por: Arnold, Jackie, et al.
Publicado: (2022)

Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes
por: Chen, Dongquan, et al.
Publicado: (2015)

Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk
por: Kornberg, Tiffany G., et al.
Publicado: (2017)

Dataset on hydrophobicity indices and differential scanning calorimetry thermograms for poly(HEMA)-based hydrogels
por: Bhat, Ankita, et al.
Publicado: (2019)

Potential in vitro model for testing the effect of exposure to nanoparticles on the lung alveolar epithelial barrier()
por: Derk, Raymond, et al.
Publicado: (2015)

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer
por: Pollard, Bette S., et al.
Publicado: (2019)

Protein self-assembly onto nanodots leads to formation of conductive bio-based hybrids
por: Hu, Xiao, et al.
Publicado: (2016)

Active Nanointerfaces Based on Enzyme Carbonic Anhydrase and Metal–Organic Framework for Carbon Dioxide Reduction
por: Liu, Qian, et al.
Publicado: (2021)

Digitoxin medication and cancer; case control and internal dose-response studies
por: Haux, Johan, et al.
Publicado: (2001)

Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine
por: Castello, Luigi M, et al.
Publicado: (2012)

Variation in pentose phosphate pathway-associated metabolism dictates cytotoxicity outcomes determined by tetrazolium reduction assays
por: Coyle, Jayme P., et al.
Publicado: (2023)

Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells
por: Einbond, Linda Saxe, et al.
Publicado: (2010)

Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro
por: Coyle, Jayme P., et al.
Publicado: (2020)

Direct stimulation of human fibroblasts by nCeO(2)in vitro is attenuated with an amorphous silica coating
por: Davidson, Donna C., et al.
Publicado: (2016)

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3
por: Chou, Jou-Chun, et al.
Publicado: (2021)

Digitoxin Affects Metabolism, ROS Production and Proliferation in Pancreatic Cancer Cells Differently Depending on the Cell Phenotype
por: Lindholm, Heléne, et al.
Publicado: (2022)

Thin Films of Metal-Organic Framework Interfaces Obtained by Laser Evaporation
por: Rose, Olivia L., et al.
Publicado: (2021)

Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial
por: Bavendiek, Udo, et al.
Publicado: (2023)

Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression
por: Yang, Qing Feng, et al.
Publicado: (2013)

Na+/K+‑ATPase subunit α3 expression is associated with the efficacy of digitoxin treatment in pancreatic cancer cells
por: Lindholm, Heléne, et al.
Publicado: (2022)

Linking JNK-STAT3-Akt signaling axis to EZH2 phosphorylation: A novel pathway of carcinogenesis
por: Rojanasakul, Yon
Publicado: (2013)

The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner
por: Schinner, Camilla, et al.
Publicado: (2020)

In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis
por: Freitas, Camila S., et al.
Publicado: (2021)

A novel E-cadherin/SOX9 axis regulates cancer stem cells in multiple myeloma by activating Akt and MAPK pathways
por: Samart, Parinya, et al.
Publicado: (2022)

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
por: Luanpitpong, Sudjit, et al.
Publicado: (2013)

Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G(2)/M cell cycle arrest and apoptosis
por: Lei, Yuhe, et al.
Publicado: (2020)

Definitive Upfront Stereotactic Ablative Radiotherapy Combined with Image-Guided, Intensity Modulated Radiotherapy (IG-IMRT) or IG-IMRT Alone for Locally Advanced Non-Small Cell Lung Cancer
por: Chi, Alexander, et al.
Publicado: (2016)

Graphene nanoplatelets-sericin surface-modified Gum alloy for improved biological response
por: Mitran, Valentina, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_54fepqg53b1h5bo83lklnjjqad