Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

BACKGROUND: The A53T mutation in the α-synuclein gene causes autosomal-dominant Lewy body Parkinson's disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of enhanced macroautophagy in patients with this mutation has not been assessed....

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Detalles Bibliográficos
Autores principales: Huang, Yue, Chegini, Fariba, Chua, Germaine, Murphy, Karen, Gai, Weiping, Halliday, Glenda M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506995/
https://www.ncbi.nlm.nih.gov/pubmed/23210740
http://dx.doi.org/10.1186/2047-9158-1-2

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