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Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease

BACKGROUND: It has been recently demonstrated that Royal jelly (RJ) has a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine the effect of RJ on spatial learning and memory in...

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Autores principales: Zamani, Zohre, Reisi, Parham, Alaei, Hojjatallah, Pilehvarian, Ali Asghar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507025/
https://www.ncbi.nlm.nih.gov/pubmed/23210085
http://dx.doi.org/10.4103/2277-9175.98150
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author Zamani, Zohre
Reisi, Parham
Alaei, Hojjatallah
Pilehvarian, Ali Asghar
author_facet Zamani, Zohre
Reisi, Parham
Alaei, Hojjatallah
Pilehvarian, Ali Asghar
author_sort Zamani, Zohre
collection PubMed
description BACKGROUND: It has been recently demonstrated that Royal jelly (RJ) has a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine the effect of RJ on spatial learning and memory in rats after intracerebroventricular injection of streptozotocin (icv-STZ). MATERIALS AND METHODS: Rats were infused bilaterally with an icv injection of STZ, while sham rats received vehicle only. The rats were feed with RJ-contained food (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular food for 10 days. Then spatial learning and memory was tested in the rats by Morris water maze test. RESULTS: Results showed that in icv-STZ group latency and path length were increased as compared to sham group, also icv-STZ rats less remembered the target quadrant that previously the platform was located; however, these were protected significantly in STZ group that received RJ-containing food. CONCLUSIONS: Our findings support the potential neuroprotective role of RJ and its helpful effects in AD.
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spelling pubmed-35070252012-12-03 Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease Zamani, Zohre Reisi, Parham Alaei, Hojjatallah Pilehvarian, Ali Asghar Adv Biomed Res Original Article BACKGROUND: It has been recently demonstrated that Royal jelly (RJ) has a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine the effect of RJ on spatial learning and memory in rats after intracerebroventricular injection of streptozotocin (icv-STZ). MATERIALS AND METHODS: Rats were infused bilaterally with an icv injection of STZ, while sham rats received vehicle only. The rats were feed with RJ-contained food (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular food for 10 days. Then spatial learning and memory was tested in the rats by Morris water maze test. RESULTS: Results showed that in icv-STZ group latency and path length were increased as compared to sham group, also icv-STZ rats less remembered the target quadrant that previously the platform was located; however, these were protected significantly in STZ group that received RJ-containing food. CONCLUSIONS: Our findings support the potential neuroprotective role of RJ and its helpful effects in AD. Medknow Publications & Media Pvt Ltd 2012-07-06 /pmc/articles/PMC3507025/ /pubmed/23210085 http://dx.doi.org/10.4103/2277-9175.98150 Text en Copyright: © 2012 Zamani. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Zamani, Zohre
Reisi, Parham
Alaei, Hojjatallah
Pilehvarian, Ali Asghar
Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease
title Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease
title_full Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease
title_fullStr Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease
title_full_unstemmed Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease
title_short Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease
title_sort effect of royal jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic alzheimer's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507025/
https://www.ncbi.nlm.nih.gov/pubmed/23210085
http://dx.doi.org/10.4103/2277-9175.98150
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