Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane

The NF2 gene encodes a tumor suppressor protein known as merlin or schwannomin whose loss of function causes Neurofibromatosis Type 2 (NF2). NF2 is characterized by the development of benign tumors, predominantly schwannomas, in the peripheral nervous system. Merlin links plasma membrane receptors w...

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Detalles Bibliográficos
Autores principales: Manetti, Maria Elisa, Geden, Sandra, Bott, Marga, Sparrow, Nicklaus, Lambert, Stephen, Fernandez-Valle, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507182/
https://www.ncbi.nlm.nih.gov/pubmed/23213372
http://dx.doi.org/10.1242/bio.20122121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507182/
https://www.ncbi.nlm.nih.gov/pubmed/23213372
http://dx.doi.org/10.1242/bio.20122121

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