ABT-737 synergizes with Bortezomib to kill melanoma cells

The BH3 mimetic ABT-737 is a potent inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L), and Bcl-w. The Bcl-2 family modulates sensitivity to anticancer drugs in many cancers, including melanomas. In this study, we examined whether ABT-737 is effective in killing melanoma cells either alone or...

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Detalles Bibliográficos
Autores principales: Reuland, Steven N., Goldstein, Nathaniel B., Partyka, Katie A., Smith, Shilo, Luo, Yuchun, Fujita, Mayumi, Gonzalez, Rene, Lewis, Karl, Norris, David A., Shellman, Yiqun G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507205/
https://www.ncbi.nlm.nih.gov/pubmed/23213401
http://dx.doi.org/10.1242/bio.2011035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507205/
https://www.ncbi.nlm.nih.gov/pubmed/23213401
http://dx.doi.org/10.1242/bio.2011035

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