Cargando…

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate. Herein, we demonstrate that the goblet cell metaplasia observed in lung airways from Hoxa5(−/−) mice originates from the transdiff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boucherat, Olivier, Chakir, Jamila, Jeannotte, Lucie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507293/ https://www.ncbi.nlm.nih.gov/pubmed/23213461 http://dx.doi.org/10.1242/bio.20121701

Ejemplares similares

Multiple Promoters and Alternative Splicing: Hoxa5 Transcriptional Complexity in the Mouse Embryo
por: Coulombe, Yan, et al.
Publicado: (2010)

Hoxa5: A Key Player in Development and Disease
por: Jeannotte, Lucie, et al.
Publicado: (2016)

High expression of sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia
por: Xu, Chengyun, et al.
Publicado: (2018)

LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia
por: Li, Yu, et al.
Publicado: (2021)

SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways
por: Tan, Dan, et al.
Publicado: (2023)

TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium
por: Centeio, Raquel, et al.
Publicado: (2023)

Conditional Loss of Hoxa5 Function Early after Birth Impacts on Expression of Genes with Synaptic Function
por: Lizen, Benoit, et al.
Publicado: (2017)

YY1 Acts as a Transcriptional Activator of Hoxa5 Gene Expression in Mouse Organogenesis
por: Bérubé-Simard, Félix-Antoine, et al.
Publicado: (2014)

Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice
por: Kurokawa, Atsushi, et al.
Publicado: (2021)

Hoxa5 Activity Across the Lateral Somitic Frontier Regulates Development of the Mouse Sternum
por: Mitchel, Kira, et al.
Publicado: (2022)

Indole-3-Carbinol Promotes Goblet-Cell Differentiation Regulating Wnt and Notch Signaling Pathways AhR-Dependently
por: Park, Joo-Hung, et al.
Publicado: (2018)

The Efficacy of 2% Topical Rebamipide on Conjunctival Squamous Metaplasia and Goblet Cell Density in Dry Eye Disease
por: Simsek, Cem, et al.
Publicado: (2019)

FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia
por: Nyeng, Pia, et al.
Publicado: (2008)

HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation
por: Holzman, Miriam A., et al.
Publicado: (2021)

Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia
por: Chung, Wen-Cheng, et al.
Publicado: (2019)

T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways
por: Chand, Hitendra S., et al.
Publicado: (2016)

Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma
por: Gao, Li, et al.
Publicado: (2022)

Study of Promoter Methylation Patterns of HOXA2, HOXA5, and HOXA6 and Its Clinicopathological Characteristics in Colorectal Cancer
por: Li, Daojiang, et al.
Publicado: (2019)

Inhibition of β-Catenin/CREB Binding Protein Signaling Attenuates House Dust Mite-Induced Goblet Cell Metaplasia in Mice
por: Kuchibhotla, Virinchi N. S., et al.
Publicado: (2021)

Inflammatory macrophages prevent colonic goblet and enteroendocrine cell differentiation through Notch signaling
por: Atanga, Roger, et al.
Publicado: (2023)

Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation
por: Sanghez, Valentina, et al.
Publicado: (2017)

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung
por: Cassandras, Monica, et al.
Publicado: (2020)

Microarray Analysis of Long Non-Coding RNAs in Lung Tissues of Patients with COPD and HOXA-AS2 Promotes HPMECs Proliferation via Notch1
por: Zhou, Ai-yuan, et al.
Publicado: (2020)

Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine
por: Morales, Rodrigo A., et al.
Publicado: (2022)

Mucus threads from surface goblet cells clear particles from the airways
por: Ermund, Anna, et al.
Publicado: (2021)

Inhibition of Gabrp reduces the differentiation of airway epithelial progenitor cells into goblet cells
por: Wang, An, et al.
Publicado: (2021)

Goblet cell interactions reorient bundled mucus strands for efficient airway clearance
por: Bos, Meike F, et al.
Publicado: (2023)

Notch inhibitors induce diarrhea, hypercrinia and secretory cell metaplasia in the human colon
por: Collins, Michael, et al.
Publicado: (2021)

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells
por: Yadav, Umesh C. S., et al.
Publicado: (2010)

Autophagy of mucin granules contributes to resolution of airway mucous metaplasia
por: Sweeter, J. M., et al.
Publicado: (2021)

Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
por: Liu, Chia-Yang
Publicado: (2015)

+HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Cao, Fengyu, et al.
Publicado: (2022)

Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18
por: Harris, J Foster, et al.
Publicado: (2007)

The Role of the Notch Signal Pathway in Mucosal Cell Metaplasia in Mouse Acute Otitis Media
por: Liu, Xiang, et al.
Publicado: (2017)

Pentraxin 3 (PTX3) Expression in Allergic Asthmatic Airways: Role in Airway Smooth Muscle Migration and Chemokine Production
por: Zhang, Jingbo, et al.
Publicado: (2012)

Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway
por: Zhou, Yuning, et al.
Publicado: (2014)

Retracted: +HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas
por: Jäger, Daniela, et al.
Publicado: (2017)

Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"
por: Raiford, Kimberly L, et al.
Publicado: (2011)

Interferon-gamma deficiency protects against aging-related goblet cell loss
por: Volpe, Eugene A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lfgkkhvq4cc73tmk3nmed3mt5f