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FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets
A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507353/ https://www.ncbi.nlm.nih.gov/pubmed/23204630 http://dx.doi.org/10.4103/0250-474X.102551 |
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author | Pandey, S. Pandey, P. Tiwari, G. Tiwari, R. Rai, A. K. |
author_facet | Pandey, S. Pandey, P. Tiwari, G. Tiwari, R. Rai, A. K. |
author_sort | Pandey, S. |
collection | PubMed |
description | A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the extraction of the active ingredient with methanol followed by phosphate buffer pH 6.0. The excipients in the commercial tablet preparation did not interfere with the assay. The specifity, linearity, detection limits, precision and accuracy of the calibration curve, drug extraction, infrared analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with other methods for quantification of ciprofloxacin. |
format | Online Article Text |
id | pubmed-3507353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35073532012-11-30 FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets Pandey, S. Pandey, P. Tiwari, G. Tiwari, R. Rai, A. K. Indian J Pharm Sci Short Communication A simple, accurate and sensitive spectroscopic method has been proposed for the assay of ciprofloxacin in tablet by least square treatment of fourier transform infrared spectrometric data obtained at the wavenumber corresponding to the carbonyl group centered at 1707 cm(-1). The method involves the extraction of the active ingredient with methanol followed by phosphate buffer pH 6.0. The excipients in the commercial tablet preparation did not interfere with the assay. The specifity, linearity, detection limits, precision and accuracy of the calibration curve, drug extraction, infrared analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with other methods for quantification of ciprofloxacin. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3507353/ /pubmed/23204630 http://dx.doi.org/10.4103/0250-474X.102551 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Pandey, S. Pandey, P. Tiwari, G. Tiwari, R. Rai, A. K. FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets |
title | FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets |
title_full | FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets |
title_fullStr | FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets |
title_full_unstemmed | FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets |
title_short | FTIR Spectroscopy: A Tool for Quantitative Analysis of Ciprofloxacin in Tablets |
title_sort | ftir spectroscopy: a tool for quantitative analysis of ciprofloxacin in tablets |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507353/ https://www.ncbi.nlm.nih.gov/pubmed/23204630 http://dx.doi.org/10.4103/0250-474X.102551 |
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