Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity

A number of key regulators of mouse embryonic stem (ES) cell identity, including the transcription factor Nanog, show strong expression fluctuations at the single cell level. The molecular basis for these fluctuations is unknown. Here we used a genetic complementation strategy to investigate express...

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Detalles Bibliográficos
Autores principales: MacArthur, Ben D., Sevilla, Ana, Lenz, Michel, Müller, Franz-Josef, Schuldt, Berhard M., Schuppert, Andreas A., Ridden, Sonya J., Stumpf, Patrick S., Fidalgo, Miguel, Ma’ayan, Avi, Wang, Jianlong, Lemischka, Ihor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507454/
https://www.ncbi.nlm.nih.gov/pubmed/23103910
http://dx.doi.org/10.1038/ncb2603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507454/
https://www.ncbi.nlm.nih.gov/pubmed/23103910
http://dx.doi.org/10.1038/ncb2603

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