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A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve funct...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507555/ https://www.ncbi.nlm.nih.gov/pubmed/22891253 http://dx.doi.org/10.2337/dc12-0028 |
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author | Chang, Jessica Russo, Antonietta Bound, Michelle Rayner, Christopher K. Jones, Karen L. Horowitz, Michael |
author_facet | Chang, Jessica Russo, Antonietta Bound, Michelle Rayner, Christopher K. Jones, Karen L. Horowitz, Michael |
author_sort | Chang, Jessica |
collection | PubMed |
description | OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years. |
format | Online Article Text |
id | pubmed-3507555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-35075552013-12-01 A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes Chang, Jessica Russo, Antonietta Bound, Michelle Rayner, Christopher K. Jones, Karen L. Horowitz, Michael Diabetes Care Original Research OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years. American Diabetes Association 2012-12 2012-11-14 /pmc/articles/PMC3507555/ /pubmed/22891253 http://dx.doi.org/10.2337/dc12-0028 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Chang, Jessica Russo, Antonietta Bound, Michelle Rayner, Christopher K. Jones, Karen L. Horowitz, Michael A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes |
title | A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes |
title_full | A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes |
title_fullStr | A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes |
title_full_unstemmed | A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes |
title_short | A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes |
title_sort | 25-year longitudinal evaluation of gastric emptying in diabetes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507555/ https://www.ncbi.nlm.nih.gov/pubmed/22891253 http://dx.doi.org/10.2337/dc12-0028 |
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