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A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes

OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve funct...

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Detalles Bibliográficos
Autores principales: Chang, Jessica, Russo, Antonietta, Bound, Michelle, Rayner, Christopher K., Jones, Karen L., Horowitz, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507555/
https://www.ncbi.nlm.nih.gov/pubmed/22891253
http://dx.doi.org/10.2337/dc12-0028
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author Chang, Jessica
Russo, Antonietta
Bound, Michelle
Rayner, Christopher K.
Jones, Karen L.
Horowitz, Michael
author_facet Chang, Jessica
Russo, Antonietta
Bound, Michelle
Rayner, Christopher K.
Jones, Karen L.
Horowitz, Michael
author_sort Chang, Jessica
collection PubMed
description OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years.
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spelling pubmed-35075552013-12-01 A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes Chang, Jessica Russo, Antonietta Bound, Michelle Rayner, Christopher K. Jones, Karen L. Horowitz, Michael Diabetes Care Original Research OBJECTIVE: To evaluate the natural history of gastric emptying in diabetes. RESEARCH DESIGN AND METHODS: Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years. RESULTS: There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17). CONCLUSIONS: In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years. American Diabetes Association 2012-12 2012-11-14 /pmc/articles/PMC3507555/ /pubmed/22891253 http://dx.doi.org/10.2337/dc12-0028 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Chang, Jessica
Russo, Antonietta
Bound, Michelle
Rayner, Christopher K.
Jones, Karen L.
Horowitz, Michael
A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
title A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
title_full A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
title_fullStr A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
title_full_unstemmed A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
title_short A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
title_sort 25-year longitudinal evaluation of gastric emptying in diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507555/
https://www.ncbi.nlm.nih.gov/pubmed/22891253
http://dx.doi.org/10.2337/dc12-0028
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