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Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control
OBJECTIVE: The glycation gap (the difference between measured A1C and the value predicted by regression on fructosamine) is stable and is associated with microvascular complications of diabetes but has not hitherto been estimated within a clinically useful time frame. We investigated whether two det...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507558/ https://www.ncbi.nlm.nih.gov/pubmed/22961579 http://dx.doi.org/10.2337/dc11-2450 |
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author | Rodríguez-Segade, Santiago Rodríguez, Javier García Lopez, José M. Casanueva, Felipe F. Camiña, Félix |
author_facet | Rodríguez-Segade, Santiago Rodríguez, Javier García Lopez, José M. Casanueva, Felipe F. Camiña, Félix |
author_sort | Rodríguez-Segade, Santiago |
collection | PubMed |
description | OBJECTIVE: The glycation gap (the difference between measured A1C and the value predicted by regression on fructosamine) is stable and is associated with microvascular complications of diabetes but has not hitherto been estimated within a clinically useful time frame. We investigated whether two determinations 30 days apart suffice for a reasonably reliable estimate if both A1C and fructosamine exhibit stability. RESEARCH DESIGN AND METHODS: We studied 311 patients with type 1 or type 2 diabetes for whom simultaneous measurements of A1C and serum fructosamine had been made on at least two occasions separated by 1 month (t(0) and t(1)). Glycemia was deemed stable if A1C(t(1)) – A1C(t(0)) and fructosamine(t(1)) − fructosamine(t(0)) were both less than their reference change values (RCVs). Instantaneous glycation gaps [gg(t(0)) and gg(t(1))] and their mean (GG), were calculated using the data from all stable patients for the required regression. RESULTS: Stable glycemia was shown by 144 patients. In 90% of unstable case subjects, a change in medication was identified as the cause of instability. Among 129 stable patients with an average of eight gg determinations prior to t(0), GG correlated closely with the mean of these prior determinations (r(2) = 0.902, slope 1.025, intercept −0.038). CONCLUSIONS: The glycation gap can be calculated reliably from pairs of A1C and fructosamine measurements taken 1 month apart if these measurements satisfy the RCV criteria for glycemic control. |
format | Online Article Text |
id | pubmed-3507558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-35075582013-12-01 Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control Rodríguez-Segade, Santiago Rodríguez, Javier García Lopez, José M. Casanueva, Felipe F. Camiña, Félix Diabetes Care Original Research OBJECTIVE: The glycation gap (the difference between measured A1C and the value predicted by regression on fructosamine) is stable and is associated with microvascular complications of diabetes but has not hitherto been estimated within a clinically useful time frame. We investigated whether two determinations 30 days apart suffice for a reasonably reliable estimate if both A1C and fructosamine exhibit stability. RESEARCH DESIGN AND METHODS: We studied 311 patients with type 1 or type 2 diabetes for whom simultaneous measurements of A1C and serum fructosamine had been made on at least two occasions separated by 1 month (t(0) and t(1)). Glycemia was deemed stable if A1C(t(1)) – A1C(t(0)) and fructosamine(t(1)) − fructosamine(t(0)) were both less than their reference change values (RCVs). Instantaneous glycation gaps [gg(t(0)) and gg(t(1))] and their mean (GG), were calculated using the data from all stable patients for the required regression. RESULTS: Stable glycemia was shown by 144 patients. In 90% of unstable case subjects, a change in medication was identified as the cause of instability. Among 129 stable patients with an average of eight gg determinations prior to t(0), GG correlated closely with the mean of these prior determinations (r(2) = 0.902, slope 1.025, intercept −0.038). CONCLUSIONS: The glycation gap can be calculated reliably from pairs of A1C and fructosamine measurements taken 1 month apart if these measurements satisfy the RCV criteria for glycemic control. American Diabetes Association 2012-12 2012-11-14 /pmc/articles/PMC3507558/ /pubmed/22961579 http://dx.doi.org/10.2337/dc11-2450 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Rodríguez-Segade, Santiago Rodríguez, Javier García Lopez, José M. Casanueva, Felipe F. Camiña, Félix Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control |
title | Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control |
title_full | Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control |
title_fullStr | Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control |
title_full_unstemmed | Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control |
title_short | Estimation of the Glycation Gap in Diabetic Patients With Stable Glycemic Control |
title_sort | estimation of the glycation gap in diabetic patients with stable glycemic control |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507558/ https://www.ncbi.nlm.nih.gov/pubmed/22961579 http://dx.doi.org/10.2337/dc11-2450 |
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