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Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin

OBJECTIVE: An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancest...

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Autores principales: Qu, Hui-Qi, Li, Quan, Lu, Yang, Hanis, Craig L., Fisher-Hoch, Susan P., McCormick, Joseph B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507582/
https://www.ncbi.nlm.nih.gov/pubmed/22891255
http://dx.doi.org/10.2337/dc12-0636
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author Qu, Hui-Qi
Li, Quan
Lu, Yang
Hanis, Craig L.
Fisher-Hoch, Susan P.
McCormick, Joseph B.
author_facet Qu, Hui-Qi
Li, Quan
Lu, Yang
Hanis, Craig L.
Fisher-Hoch, Susan P.
McCormick, Joseph B.
author_sort Qu, Hui-Qi
collection PubMed
description OBJECTIVE: An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR. RESEARCH DESIGN AND METHODS: We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0–100%) ancestry from three major continental populations, i.e., European, African, and Amerindian. RESULTS: We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (β = 0.124, P = 1.64 × 10(−7)). The correlation was more significant in males (Amerindian β = 0.165, P = 5.08 × 10(−7)) than in females (Amerindian β = 0.079, P = 0.019). CONCLUSIONS: This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance.
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spelling pubmed-35075822013-12-01 Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin Qu, Hui-Qi Li, Quan Lu, Yang Hanis, Craig L. Fisher-Hoch, Susan P. McCormick, Joseph B. Diabetes Care Original Research OBJECTIVE: An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR. RESEARCH DESIGN AND METHODS: We performed ancestral analysis in 1,551 participants of the Cameron County Hispanic Cohort by genotyping 103 ancestry-informative markers (AIMs). These AIMs allow determination of the percentage (0–100%) ancestry from three major continental populations, i.e., European, African, and Amerindian. RESULTS: We observed that predominantly Amerindian ancestral components were associated with increased HOMA-IR (β = 0.124, P = 1.64 × 10(−7)). The correlation was more significant in males (Amerindian β = 0.165, P = 5.08 × 10(−7)) than in females (Amerindian β = 0.079, P = 0.019). CONCLUSIONS: This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance. American Diabetes Association 2012-12 2012-11-14 /pmc/articles/PMC3507582/ /pubmed/22891255 http://dx.doi.org/10.2337/dc12-0636 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Qu, Hui-Qi
Li, Quan
Lu, Yang
Hanis, Craig L.
Fisher-Hoch, Susan P.
McCormick, Joseph B.
Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
title Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
title_full Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
title_fullStr Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
title_full_unstemmed Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
title_short Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
title_sort ancestral effect on homa-ir levels quantitated in an american population of mexican origin
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507582/
https://www.ncbi.nlm.nih.gov/pubmed/22891255
http://dx.doi.org/10.2337/dc12-0636
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