Cargando…

The Crystal Structure of the Intact E. coli RelBE Toxin-Antitoxin Complex Provides the Structural Basis for Conditional Cooperativity

The bacterial relBE locus encodes a toxin-antitoxin complex in which the toxin, RelE, is capable of cleaving mRNA in the ribosomal A site cotranslationally. The antitoxin, RelB, both binds and inhibits RelE, and regulates transcription through operator binding and conditional cooperativity controlle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bøggild, Andreas, Sofos, Nicholas, Andersen, Kasper R., Feddersen, Ane, Easter, Ashley D., Passmore, Lori A., Brodersen, Ditlev E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Short Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507626/ https://www.ncbi.nlm.nih.gov/pubmed/22981948 http://dx.doi.org/10.1016/j.str.2012.08.017

Ejemplares similares

Interactions of the Streptococcus pneumoniae Toxin-Antitoxin RelBE Proteins with Their Target DNA
por: Moreno-Córdoba, Inmaculada, et al.
Publicado: (2021)

Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488
por: Li, Peng, et al.
Publicado: (2016)

Functional RelBE-Family Toxin-Antitoxin Pairs Affect Biofilm Maturation and Intestine Colonization in Vibrio cholerae
por: Wang, Yuning, et al.
Publicado: (2015)

The relBE2Spn Toxin-Antitoxin System of Streptococcus pneumoniae: Role in Antibiotic Tolerance and Functional Conservation in Clinical Isolates
por: Nieto, Concha, et al.
Publicado: (2010)

The Streptococcus pneumoniae yefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation
por: Chan, Wai Ting, et al.
Publicado: (2018)

Effect of mazEF, higBA and relBE toxin-antitoxin systems on antibiotic resistance in Pseudomonas aeruginosa and Staphylococcus isolates
por: Coskun, Umut Safiye Say, et al.
Publicado: (2018)

RelB and Neuroinflammation
por: Mockenhaupt, Karli, et al.
Publicado: (2021)

Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly
por: Dienemann, Christian, et al.
Publicado: (2011)

Discovery of a novel type IIb RelBE toxin‐antitoxin system in Mycobacterium tuberculosis defined by co‐regulation with an antisense RNA
por: Dawson, Clinton C., et al.
Publicado: (2022)

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB
por: Overgaard, Martin, et al.
Publicado: (2009)

Phylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations
por: Gerdes, Kenn, et al.
Publicado: (2021)

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
por: Neubauer, Cajetan, et al.
Publicado: (2009)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
por: Kabacaoglu, Derya, et al.
Publicado: (2019)

The mitochondrial localization of RelB and NFATx in immature T cells
por: Stasik, Izabela, et al.
Publicado: (2008)

RelB regulates the homeostatic proliferation but not the function of Tregs
por: Zhou, Shuping, et al.
Publicado: (2020)

Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system
por: Bærentsen, René L, et al.
Publicado: (2023)

RelB-Dependent Stromal Cells Promote T-Cell Leukemogenesis
por: dos Santos, Nuno R., et al.
Publicado: (2008)

p50–NF-κB Complexes Partially Compensate for the Absence of RelB: Severely Increased Pathology in p50(−) (/−) relB(−) (/−)Double-knockout Mice
por: Weih, Falk, et al.
Publicado: (1997)

Characterization of the Interaction and Cross-Regulation of Three Mycobacterium tuberculosis RelBE Modules
por: Yang, Min, et al.
Publicado: (2010)

Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin–antitoxin operon
por: Dominguez-Molina, Lucia, et al.
Publicado: (2023)

The NF-κB RelB Protein Is an Oncogenic Driver of Mesenchymal Glioma
por: Lee, Dong Whan, et al.
Publicado: (2013)

Frequent Engagement of RelB Activation Is Critical for Cell Survival in Multiple Myeloma
por: Cormier, Françoise, et al.
Publicado: (2013)

A link between RelB expression and tumor progression in laryngeal cancer
por: Giopanou, Ioanna, et al.
Publicado: (2017)

Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice
por: O’Sullivan, Brendan J., et al.
Publicado: (2018)

Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression
por: Wang, Meng, et al.
Publicado: (2018)

Prototype foamy virus downregulates RelB expression to facilitate viral replication
por: Zhang, Junshi, et al.
Publicado: (2020)

RelB is a potential molecular biomarker for immunotherapy in human pan-cancer
por: Wu, Jintao, et al.
Publicado: (2023)

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
por: Lovas, Agnes, et al.
Publicado: (2008)

Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
por: Baud, Véronique, et al.
Publicado: (2016)

Prognostic significance of RelB overexpression in non‐small cell lung cancer patients
por: Qin, Hualong, et al.
Publicado: (2016)

A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis
por: Gupta, Angela S., et al.
Publicado: (2019)

RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme
por: Waters, Michael R., et al.
Publicado: (2019)

RelB upregulates PD-L1 and exacerbates prostate cancer immune evasion
por: Zhang, Yanyan, et al.
Publicado: (2022)

Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression
por: Sun, Donglin, et al.
Publicado: (2021)

Unrelated toxin–antitoxin systems cooperate to induce persistence
por: Fasani, Rick A., et al.
Publicado: (2015)

Club Cell-16 and RelB as Novel Determinants of Arterial Stiffness in Exacerbating COPD Patients
por: Labonté, Laura E., et al.
Publicado: (2016)

Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer
por: Lawrence, Cortney L., et al.
Publicado: (2016)

RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis
por: Shen, Feng, et al.
Publicado: (2018)

RelB promotes liver fibrosis via inducing the release of injury‐associated inflammatory cytokines
por: Zhou, Danhua, et al.
Publicado: (2020)

A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
por: Lalle, Guilhem, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4spo7gqn94o2v7o3du5ieju845