Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

Here we show that Rab25 permits the sorting of ligand-occupied, active-conformation α5β1 integrin to late endosomes/lysosomes. Photoactivation and biochemical approaches show that lysosomally targeted integrins are not degraded but are retrogradely transported and recycled to the plasma membrane at...

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Detalles Bibliográficos
Autores principales: Dozynkiewicz, Marta A., Jamieson, Nigel B., MacPherson, Iain, Grindlay, Joan, van den Berghe, Peter V.E., von Thun, Anne, Morton, Jennifer P., Gourley, Charlie, Timpson, Paul, Nixon, Colin, McKay, Colin J., Carter, Ross, Strachan, David, Anderson, Kurt, Sansom, Owen J., Caswell, Patrick T., Norman, Jim C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507630/
https://www.ncbi.nlm.nih.gov/pubmed/22197222
http://dx.doi.org/10.1016/j.devcel.2011.11.008

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