Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants

BACKGROUND: Human TWIST1 is a highly conserved member of the regulatory basic helix-loop-helix (bHLH) transcription factors. TWIST1 forms homo- or heterodimers with E-box proteins, such as E2A (isoforms E12 and E47), MYOD and HAND2. Haploinsufficiency germ-line mutations of the twist1 gene in humans...

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Detalles Bibliográficos
Autores principales: Maia, Amanda M, da Silva, João HM, Mencalha, André L, Caffarena, Ernesto R, Abdelhay, Eliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507644/
https://www.ncbi.nlm.nih.gov/pubmed/22839202
http://dx.doi.org/10.1186/1471-2105-13-184

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