T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy

Tumor antigen-reactive T cells must enter into an immunosuppressive tumor microenvironment, continue to produce cytokine and deliver apoptotic death signals to affect tumor regression. Many tumors produce transforming growth factor beta (TGFβ), which inhibits T cell activation, proliferation and cyt...

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Detalles Bibliográficos
Autores principales: Quatromoni, Jon G, Wang, Yue, Vo, Dan D, Morris, Lilah F, Jazirehi, Ali R, McBride, William, Chatila, Talal, Koya, Richard C, Economou, James S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507675/
https://www.ncbi.nlm.nih.gov/pubmed/22713761
http://dx.doi.org/10.1186/1479-5876-10-127

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