Cargando…

Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer’s disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precise Aβ species to target is not yet known. Previously,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Welzel, Alfred T., Williams, Angela D., McWilliams-Koeppen, Helen P., Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A., Ehrlich, Hartmut J., Schwarz, Hans P., Walsh, Dominic M., Solomon, Alan, O’Nuallain, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507685/ https://www.ncbi.nlm.nih.gov/pubmed/23209707 http://dx.doi.org/10.1371/journal.pone.0050317

Ejemplares similares

Anti-amyloidogenic Activity of IgGs Contained in Normal Plasma
por: O’Nuallain, Brian, et al.
Publicado: (2010)

IgG Conformer's Binding to Amyloidogenic Aggregates
por: Phay, Monichan, et al.
Publicado: (2015)

IgGs drive COVID-19 myeloid hyperinflammation
por: Park, Matthew D.
Publicado: (2020)

Is Europe prepared to go digital? making the case for developing digital capacity: An exploratory analysis of Eurostat survey data
por: van Kessel, Robin, et al.
Publicado: (2022)

Production of antigen-specific human IgGs by in vitro immunization
por: Wijkhuisen, A., et al.
Publicado: (2016)

Glycomic Signatures on Serum IgGs for Prediction of Postvaccination Response
por: Wang, Jing-Rong, et al.
Publicado: (2015)

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy
por: Jordan, Robert E., et al.
Publicado: (2018)

IgGs from Human Milk Hydrolyze microRNAs
por: Kompaneets, Ivan Yu., et al.
Publicado: (2020)

Selectivity over coverage in de novo sequencing of IgGs
por: den Boer, Maurits A., et al.
Publicado: (2020)

Production of IgGs with a human-like sialylation in CHO cells
por: Raymond, Céline, et al.
Publicado: (2015)

Neuronal intermediate filament IgGs in CSF: Autoimmune Axonopathy Biomarkers
por: McKeon, Andrew, et al.
Publicado: (2020)

Non-Apical Membrane Antigen 1 (AMA1) IgGs from Malian Children Interfere with Functional Activity of AMA1 IgGs as Judged by Growth Inhibition Assay
por: Miura, Kazutoyo, et al.
Publicado: (2011)

Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds
por: Vaks, Lilach, et al.
Publicado: (2018)

Catalase Activity of IgGs of Patients Infected with SARS-CoV-2
por: Tolmacheva, Anna S., et al.
Publicado: (2023)

BEAT(® )the bispecific challenge: a novel and efficient platform for the expression of bispecific IgGs
por: Moretti, Pierre, et al.
Publicado: (2013)

Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein
por: Kamaeva, Daria A., et al.
Publicado: (2022)

Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG: Evidence of Epitope Masking
por: Bergström, Joakim J. E., et al.
Publicado: (2017)

Nano-visualization of oriented-immobilized IgGs on immunosensors by high-speed atomic force microscopy
por: Iijima, Masumi, et al.
Publicado: (2012)

IgGs-Abzymes from the Sera of Patients with Systemic Lupus Erythematosus Hydrolyzed miRNAs
por: Ermakov, Evgeny A, et al.
Publicado: (2020)

Natural Catalytic IgGs Hydrolyzing Histones in Schizophrenia: Are They the Link between Humoral Immunity and Inflammation?
por: Ermakov, Evgeny A., et al.
Publicado: (2020)

Impact of Glycosylation and Species Origin on the Uptake and Permeation of IgGs through the Nasal Airway Mucosa
por: Ladel, Simone, et al.
Publicado: (2020)

IgGs-Abzymes from the Sera of Patients with Multiple Sclerosis Recognize and Hydrolyze miRNAs
por: Ermakov, Evgeny A., et al.
Publicado: (2021)

Experimental Autoimmune Encephalomyelitis of Mice: IgGs from the Sera of Mice Hydrolyze miRNAs
por: Nevinsky, Georgy A., et al.
Publicado: (2023)

Digital Health Paradox: International Policy Perspectives to Address Increased Health Inequalities for People Living With Disabilities
por: van Kessel, Robin, et al.
Publicado: (2022)

Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry
por: Phung, Wilson, et al.
Publicado: (2020)

Antibody germline characterization of cross-neutralizing human IgGs against 4 serotypes of dengue virus
por: Pitaksajjakul, Pannamthip, et al.
Publicado: (2014)

Behind the scenes of GS: preventing and curing - the GS-SE group
por: CERN, GS-SE
Publicado: (2013)

Autoantibodies targeting tumor-associated antigens in metastatic cancer: Sialylated IgGs as candidate anti-inflammatory antibodies
por: Oaks, Martin, et al.
Publicado: (2013)

Detection of IgM Antibrucella Antibody in the Absence of IgGs: A Challenge for the Clinical Interpretation of Brucella Serology
por: Solís García del Pozo, Julián, et al.
Publicado: (2014)

Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis
por: Xiao, Nanping, et al.
Publicado: (2018)

GS BBQ 2015
por: Rueda, Laura
Publicado: (2015)

Human Milk IgGs Contain Various Combinations of Different Antigen-Binding Sites Resulting in Multiple Variants of their Bispecificity
por: Sedykh, Sergey E., et al.
Publicado: (2012)

Affinity and catalytic heterogeneity of polyclonal myelin basic protein-hydrolyzing IgGs from sera of patients with multiple sclerosis
por: Legostaeva, Galina A, et al.
Publicado: (2010)

Circulating IgGs in Type 2 Diabetes with Atrial Fibrillation Induce IP(3)-Mediated Calcium Elevation in Cardiomyocytes
por: Luo, Yanhong, et al.
Publicado: (2020)

Differential binding of human and murine IgGs to catalytic and cell wall binding domains of Staphylococcus aureus peptidoglycan hydrolases
por: Wang, Min, et al.
Publicado: (2021)

Pion photoproduction and the "anomalous" transition $^{14}$N$_{g.s.}$ --> $^{14}$C$_{g.s.}$
por: Figureau, A, et al.
Publicado: (1980)

Behind the scenes of GS: preventing and curing - the GS-SE group (VERSION FR)
por: CERN, GS-SE
Publicado: (2013)

Plasmodium falciparum immunodominant IgG epitopes in subclinical malaria
por: Azcárate, Isabel G., et al.
Publicado: (2020)

Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common C(H)2 cleavages in IgGs and IgG-like bispecific antibodies
por: Cao, Mingyan, et al.
Publicado: (2021)

Engineered humanized dimeric forms of IgG are more effective antibodies
Publicado: (1992)

Cannot write session to /tmp/vufind_sessions/sess_bovlakn9m9bfl55u2k2odvknep