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Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer’s disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precise Aβ species to target is not yet known. Previously,...

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Detalles Bibliográficos
Autores principales:	Welzel, Alfred T., Williams, Angela D., McWilliams-Koeppen, Helen P., Acero, Luis, Weber, Alfred, Blinder, Veronika, Mably, Alex, Bunk, Sebastian, Hermann, Corinna, Farrell, Michael A., Ehrlich, Hartmut J., Schwarz, Hans P., Walsh, Dominic M., Solomon, Alan, O’Nuallain, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507685/ https://www.ncbi.nlm.nih.gov/pubmed/23209707 http://dx.doi.org/10.1371/journal.pone.0050317

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