Cargando…

Sequential Activation of Classic PKC and Estrogen Receptor α Is Involved in Estradiol 17ß-D-Glucuronide-Induced Cholestasis

Estradiol 17ß-d-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways play complementary roles in E17...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barosso, Ismael R., Zucchetti, Andrés E., Boaglio, Andrea C., Larocca, M. Cecilia, Taborda, Diego R., Luquita, Marcelo G., Roma, Marcelo G., Crocenzi, Fernando A., Sánchez Pozzi, Enrique J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507741/ https://www.ncbi.nlm.nih.gov/pubmed/23209816 http://dx.doi.org/10.1371/journal.pone.0050711

Ejemplares similares

ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K
por: Boaglio, Andrea C., et al.
Publicado: (2012)

Prevention of estradiol 17β-d-glucuronide–induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes
por: Zucchetti, Andrés E., et al.
Publicado: (2011)

Adaptive downregulation of Cl(-)/HCO(3)(-) exchange activity in rat hepatocytes under experimental obstructive cholestasis
por: Miszczuk, Gisel S., et al.
Publicado: (2019)

Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis
por: Gallucci, Gina M., et al.
Publicado: (2021)

Biotransformation of Bisphenol AF to Its Major Glucuronide Metabolite Reduces Estrogenic Activity
por: Li, Ming, et al.
Publicado: (2013)

Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide
por: Noorlander, Annelies, et al.
Publicado: (2020)

At-home urine estrone-3-glucuronide quantification predicts oocyte retrieval outcomes comparably with serum estradiol
por: Nakhuda, Gary S., et al.
Publicado: (2023)

The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
por: Zu, Yue, et al.
Publicado: (2021)

Sequential posttranslational modifications regulate PKC degradation
por: Wang, Yan, et al.
Publicado: (2016)

Achieving Physiologic 17-ẞ-Estradiol Levels in Transgender Females on Estradiol Transdermal Patches and Optimal Dosing
por: Trovato, Alexa, et al.
Publicado: (2021)

Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens
por: He, Liangliang, et al.
Publicado: (2022)

miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3
por: Rao, Zhou-Zhou, et al.
Publicado: (2017)

Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling
por: Gramec Skledar, Darja, et al.
Publicado: (2018)

3D Model of Lamprey Estrogen Receptor with Estradiol and 15α-Hydroxy-Estradiol
por: Baker, Michael E., et al.
Publicado: (2009)

Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide
por: de Hoogd, Sjoerd, et al.
Publicado: (2017)

Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems()
por: Wlcek, Katrin, et al.
Publicado: (2014)

Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα
por: Rosato, Benedetta, et al.
Publicado: (2018)

Systemic estradiol levels with low-dose vaginal estrogens
por: Santen, Richard J., et al.
Publicado: (2019)

Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds
por: Barreto, George E., et al.
Publicado: (2021)

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution
por: Paris, Mathilde, et al.
Publicado: (2008)

Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes
por: Kutsuno, Yuki, et al.
Publicado: (2013)

Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients
por: Franken, Linda G., et al.
Publicado: (2015)

Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows
por: Schwartz-Zimmermann, Heidi E., et al.
Publicado: (2017)

The Use of Estrone-3-Glucuronide and Pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity
por: Blackwell, Leonard F., et al.
Publicado: (2018)

Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes
por: Garg, Rachana, et al.
Publicado: (2013)

Estradiol accelerates liver regeneration through estrogen receptor α
por: Tsugawa, Yoji, et al.
Publicado: (2019)

Ontogeny of midazolam glucuronidation in preterm infants
por: de Wildt, Saskia N., et al.
Publicado: (2009)

Morphine-3-Glucuronide, Physiology and Behavior
por: Gabel, Florian, et al.
Publicado: (2022)

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions
por: Perreault, Martin, et al.
Publicado: (2018)

Combination Treatments with the PKC Inhibitor, Enzastaurin, Enhance the Cytotoxicity of the Anti-Mesothelin Immunotoxin, SS1P
por: Mattoo, Abid R., et al.
Publicado: (2013)

Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression
por: Kim, Min Ju, et al.
Publicado: (2018)

17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling
por: Kusch, Angelika, et al.
Publicado: (2015)

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis
por: Koo, Kyoung-Hwa, et al.
Publicado: (2015)

The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
por: MacLusky, Neil J., et al.
Publicado: (2005)

During development, 17alpha-estradiol is a potent estrogen and carcinogen.
por: Hajek, R A, et al.
Publicado: (1997)

Modulation of uterine morphology and growth by estradiol-17beta and an estrogen antagonist
Publicado: (1975)

Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing
por: Bhat-Nakshatri, Poornima, et al.
Publicado: (2013)

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells
por: Zeng, Xuejun, et al.
Publicado: (2016)

Cholestasis in Benign Recurrent Intrahepatic Cholestasis 2
por: Arthur Lorio, Eric, et al.
Publicado: (2020)

Induction of ß Cell Replication by Small Molecule-Mediated Menin Inhibition and Combined PKC Activation and TGF-ß Inhibition as Revealed by A Refined Primary Culture Screening
por: Pahlavanneshan, Saghar, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_77d3k86h15g97pjavc4tl9i3i3