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Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report

BACKGROUND: Leiomyosarcoma (LMS) of the gastrointestinal tract is an extremely rare high-grade neoplasm with poor prognosis. For advanced LMS with distant metastasis, the decision as to the choice of the most appropriate therapeutic strategy, including chemotherapy and surgery, is difficult. Here, w...

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Autores principales: Hamai, Yoichi, Hihara, Jun, Emi, Manabu, Aoki, Yoshiro, Kushitani, Kei, Tanabe, Kazuaki, Okada, Morihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507816/
https://www.ncbi.nlm.nih.gov/pubmed/22849696
http://dx.doi.org/10.1186/1471-230X-12-98
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author Hamai, Yoichi
Hihara, Jun
Emi, Manabu
Aoki, Yoshiro
Kushitani, Kei
Tanabe, Kazuaki
Okada, Morihito
author_facet Hamai, Yoichi
Hihara, Jun
Emi, Manabu
Aoki, Yoshiro
Kushitani, Kei
Tanabe, Kazuaki
Okada, Morihito
author_sort Hamai, Yoichi
collection PubMed
description BACKGROUND: Leiomyosarcoma (LMS) of the gastrointestinal tract is an extremely rare high-grade neoplasm with poor prognosis. For advanced LMS with distant metastasis, the decision as to the choice of the most appropriate therapeutic strategy, including chemotherapy and surgery, is difficult. Here, we present an unusual case of LMS of the sigmoid colon with liver metastases and gastric cancer. The survival of this patient was prolonged by a combined modality therapy involving chemotherapy and surgery. CASE PRESENTATION: A 66-year-old woman who had been diagnosed with advanced gastric cancer and multiple liver metastases was referred to our hospital. The initial treatment with docetaxel and S-1 considerably reduced both the gastric cancer and liver tumors; consequently we performed surgical resection. Pathological examination revealed that no viable tumor cells remained in the stomach and chemotherapy resulted in complete remission of the gastric cancer. The liver tumors were immunohistochemically diagnosed as LMS. A tumor of the sigmoid colon was subsequently discovered and the liver tumors were found to have recurred. The surgically resected sigmoid colon and liver tumors were all immunohistochemically diagnosed as LMS. These findings indicated that the multiple liver metastases arose from the LMS in the sigmoid colon, and that they were accompanied by advanced gastric cancer. We performed another surgical resection and administered chemotherapy to treat the recurring liver metastases. The patient survived for 4 years and 10 months after initial presentation at our hospital. CONCLUSION: Colonic LMS is rare and its joint occurrence with gastric cancer is extremely unusual. Although LMS is a high-grade neoplasm, a multimodal therapeutic approach can increase patient survival time even when multiple liver metastases are present.
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spelling pubmed-35078162012-11-28 Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report Hamai, Yoichi Hihara, Jun Emi, Manabu Aoki, Yoshiro Kushitani, Kei Tanabe, Kazuaki Okada, Morihito BMC Gastroenterol Case Report BACKGROUND: Leiomyosarcoma (LMS) of the gastrointestinal tract is an extremely rare high-grade neoplasm with poor prognosis. For advanced LMS with distant metastasis, the decision as to the choice of the most appropriate therapeutic strategy, including chemotherapy and surgery, is difficult. Here, we present an unusual case of LMS of the sigmoid colon with liver metastases and gastric cancer. The survival of this patient was prolonged by a combined modality therapy involving chemotherapy and surgery. CASE PRESENTATION: A 66-year-old woman who had been diagnosed with advanced gastric cancer and multiple liver metastases was referred to our hospital. The initial treatment with docetaxel and S-1 considerably reduced both the gastric cancer and liver tumors; consequently we performed surgical resection. Pathological examination revealed that no viable tumor cells remained in the stomach and chemotherapy resulted in complete remission of the gastric cancer. The liver tumors were immunohistochemically diagnosed as LMS. A tumor of the sigmoid colon was subsequently discovered and the liver tumors were found to have recurred. The surgically resected sigmoid colon and liver tumors were all immunohistochemically diagnosed as LMS. These findings indicated that the multiple liver metastases arose from the LMS in the sigmoid colon, and that they were accompanied by advanced gastric cancer. We performed another surgical resection and administered chemotherapy to treat the recurring liver metastases. The patient survived for 4 years and 10 months after initial presentation at our hospital. CONCLUSION: Colonic LMS is rare and its joint occurrence with gastric cancer is extremely unusual. Although LMS is a high-grade neoplasm, a multimodal therapeutic approach can increase patient survival time even when multiple liver metastases are present. BioMed Central 2012-07-31 /pmc/articles/PMC3507816/ /pubmed/22849696 http://dx.doi.org/10.1186/1471-230X-12-98 Text en Copyright ©2012 Hamai et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hamai, Yoichi
Hihara, Jun
Emi, Manabu
Aoki, Yoshiro
Kushitani, Kei
Tanabe, Kazuaki
Okada, Morihito
Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
title Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
title_full Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
title_fullStr Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
title_full_unstemmed Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
title_short Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
title_sort leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507816/
https://www.ncbi.nlm.nih.gov/pubmed/22849696
http://dx.doi.org/10.1186/1471-230X-12-98
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