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Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Cytokines dimerize their receptors, with binding of the “second chain” triggering signaling. In the interleukin (IL)-4/13 system, different cell types express varying levels of alternative second receptor chains (γc or IL-13Rα1), forming functionally distinct Type-I or Type-II complexes. We manipula...

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Detalles Bibliográficos
Autores principales:	Junttila, Ilkka S., Creusot, Remi J., Moraga, Ignacio, Bates, Darren L., Wong, Michael T., Alonso, Michael N., Suhoski, Megan M., Lupardus, Patrick, Meier-Schellersheim, Martin, Engleman, Edgar G., Utz, Paul J., Fathman, C. Garrison, Paul, William E., Garcia, K. Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508151/ https://www.ncbi.nlm.nih.gov/pubmed/23103943 http://dx.doi.org/10.1038/nchembio.1096

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