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The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors
In ion channels, “rings” of ionized side chains that decorate the walls of the permeation pathway often lower the energetic barrier to ion conduction. Using single-channel electrophysiological recordings, we studied the poorly understood ring of four glutamates (and one glutamine) that dominate this...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508336/ https://www.ncbi.nlm.nih.gov/pubmed/23064317 http://dx.doi.org/10.1038/nchembio.1092 |