Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Under endoplasmic reticulum (ER) stress, unfolded proteins accumulate in the ER to activate the ER transmembrane kinase/endoribonuclease (RNase)—IRE1α. IRE1α oligomerizes, autophosphorylates, and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Here we show that...

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Detalles Bibliográficos
Autores principales: Wang, Likun, Perera, B. Gayani K., Hari, Sanjay B., Bhhatarai, Barun, Backes, Bradley J., Seeliger, Markus A., Schürer, Stephan C., Oakes, Scott A., Papa, Feroz R., Maly, Dustin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508346/
https://www.ncbi.nlm.nih.gov/pubmed/23086298
http://dx.doi.org/10.1038/nchembio.1094

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