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Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration
In most solid cancers, cells harboring oncogenic mutations represent only a sub-fraction of the entire population. Within this sub-fraction the expression level of mutated proteins can vary significantly due to cellular variability limiting the efficiency of targeted therapy. To address the causes o...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508424/ https://www.ncbi.nlm.nih.gov/pubmed/23226133 http://dx.doi.org/10.3389/fphys.2012.00451 |