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Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection
BACKGROUND: The purpose of this study is to determine whether elderly subjects with severe brain atrophy, which is associated with neurodegeneration and difficulty swallowing (dysphagia), are more susceptible to lower respiratory tract infections (LRTI), including pneumonia. METHODS: The severity of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508559/ https://www.ncbi.nlm.nih.gov/pubmed/23204841 http://dx.doi.org/10.2147/CIA.S36289 |
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author | Okada, Rieko Okada, Takashi Okada, Akira Muramoto, Hideyuki Katsuno, Masahisa Sobue, Gen Hamajima, Nobuyuki |
author_facet | Okada, Rieko Okada, Takashi Okada, Akira Muramoto, Hideyuki Katsuno, Masahisa Sobue, Gen Hamajima, Nobuyuki |
author_sort | Okada, Rieko |
collection | PubMed |
description | BACKGROUND: The purpose of this study is to determine whether elderly subjects with severe brain atrophy, which is associated with neurodegeneration and difficulty swallowing (dysphagia), are more susceptible to lower respiratory tract infections (LRTI), including pneumonia. METHODS: The severity of brain atrophy was assessed by computed tomography in 51 nursing home residents aged 60–96 years. The incidence of LRTI, defined by body temperature ≥ 38.0°C, presence of two or more respiratory symptoms, and use of antibiotics, was determined over 4 years. The incidence of LRTI was compared according to the severity and type of brain atrophy. RESULTS: The incidence rate ratio of LRTI was significantly higher (odds ratio 4.60, 95% confidence interval 1.18–17.93, fully adjusted P = 0.028) and the time to the first episode of LRTI was significantly shorter (log-rank test, P = 0.019) in subjects with severe brain atrophy in any lobe. Frontal and parietal lobe atrophy was associated with a significantly increased risk of LRTI, while temporal lobe atrophy, ventricular dilatation, and diffuse white matter lesions did not influence the risk of LRTI. CONCLUSION: Elderly subjects with severe brain atrophy are more susceptible to LRTI, possibly as a result of neurodegeneration causing dysphagia and silent aspiration. Assessing the severity of brain atrophy might be useful to identify subjects at increased risk of respiratory infections in a prospective manner. |
format | Online Article Text |
id | pubmed-3508559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35085592012-11-30 Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection Okada, Rieko Okada, Takashi Okada, Akira Muramoto, Hideyuki Katsuno, Masahisa Sobue, Gen Hamajima, Nobuyuki Clin Interv Aging Original Research BACKGROUND: The purpose of this study is to determine whether elderly subjects with severe brain atrophy, which is associated with neurodegeneration and difficulty swallowing (dysphagia), are more susceptible to lower respiratory tract infections (LRTI), including pneumonia. METHODS: The severity of brain atrophy was assessed by computed tomography in 51 nursing home residents aged 60–96 years. The incidence of LRTI, defined by body temperature ≥ 38.0°C, presence of two or more respiratory symptoms, and use of antibiotics, was determined over 4 years. The incidence of LRTI was compared according to the severity and type of brain atrophy. RESULTS: The incidence rate ratio of LRTI was significantly higher (odds ratio 4.60, 95% confidence interval 1.18–17.93, fully adjusted P = 0.028) and the time to the first episode of LRTI was significantly shorter (log-rank test, P = 0.019) in subjects with severe brain atrophy in any lobe. Frontal and parietal lobe atrophy was associated with a significantly increased risk of LRTI, while temporal lobe atrophy, ventricular dilatation, and diffuse white matter lesions did not influence the risk of LRTI. CONCLUSION: Elderly subjects with severe brain atrophy are more susceptible to LRTI, possibly as a result of neurodegeneration causing dysphagia and silent aspiration. Assessing the severity of brain atrophy might be useful to identify subjects at increased risk of respiratory infections in a prospective manner. Dove Medical Press 2012 2012-11-12 /pmc/articles/PMC3508559/ /pubmed/23204841 http://dx.doi.org/10.2147/CIA.S36289 Text en © 2012 Okada et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Okada, Rieko Okada, Takashi Okada, Akira Muramoto, Hideyuki Katsuno, Masahisa Sobue, Gen Hamajima, Nobuyuki Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
title | Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
title_full | Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
title_fullStr | Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
title_full_unstemmed | Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
title_short | Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
title_sort | severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508559/ https://www.ncbi.nlm.nih.gov/pubmed/23204841 http://dx.doi.org/10.2147/CIA.S36289 |
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