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Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity

Voltage-gated sodium selective ion channel Na(V)1.5 is expressed in the heart and the gastrointestinal tract, which are mechanically active organs. Na(V)1.5 is mechanosensitive at stimuli that gate other mechanosensitive ion channels. Local anesthetic and antiarrhythmic drugs act upon Na(V)1.5 to mo...

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Detalles Bibliográficos
Autores principales:	Beyder, Arthur, Strege, Peter R., Bernard, Cheryl, Farrugia, Gianrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508909/ https://www.ncbi.nlm.nih.gov/pubmed/22874086 http://dx.doi.org/10.4161/chan.21202

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