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Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder

BACKGROUND: Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction of the orbitofrontal cortex in children with OCD. METHODS: The Iowa Gambling Tas...

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Autores principales: Kodaira, Masaki, Iwadare, Yoshitaka, Ushijima, Hirokage, Oiji, Arata, Kato, Motoichiro, Sugiyama, Nobuhiro, Sasayama, Daimei, Usami, Masahide, Watanabe, Kyota, Saito, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508952/
https://www.ncbi.nlm.nih.gov/pubmed/23062199
http://dx.doi.org/10.1186/1744-859X-11-25
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author Kodaira, Masaki
Iwadare, Yoshitaka
Ushijima, Hirokage
Oiji, Arata
Kato, Motoichiro
Sugiyama, Nobuhiro
Sasayama, Daimei
Usami, Masahide
Watanabe, Kyota
Saito, Kazuhiko
author_facet Kodaira, Masaki
Iwadare, Yoshitaka
Ushijima, Hirokage
Oiji, Arata
Kato, Motoichiro
Sugiyama, Nobuhiro
Sasayama, Daimei
Usami, Masahide
Watanabe, Kyota
Saito, Kazuhiko
author_sort Kodaira, Masaki
collection PubMed
description BACKGROUND: Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction of the orbitofrontal cortex in children with OCD. METHODS: The Iowa Gambling Task (IGT), which reflects orbitofrontal cortex function, and the Wisconsin Card Sorting Test (WCST), which is associated with functioning of the dorsolateral prefrontal cortex, were administered to 22 children with OCD and 22 healthy controls matched for gender, age, and intelligence. RESULTS: OCD patients displayed poor performance on the IGT. In contrast, performance on the WCST was not impaired in OCD patients compared to controls. CONCLUSIONS: These findings are in line with previous studies demonstrating that OCD in childhood is associated with a dysfunction of orbitofrontal-striatal-thalamic circuitry.
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spelling pubmed-35089522012-11-29 Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder Kodaira, Masaki Iwadare, Yoshitaka Ushijima, Hirokage Oiji, Arata Kato, Motoichiro Sugiyama, Nobuhiro Sasayama, Daimei Usami, Masahide Watanabe, Kyota Saito, Kazuhiko Ann Gen Psychiatry Primary Research BACKGROUND: Several lines of evidence implicate orbitofrontal cortex dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). The purpose of this study was to investigate neuropsychological dysfunction of the orbitofrontal cortex in children with OCD. METHODS: The Iowa Gambling Task (IGT), which reflects orbitofrontal cortex function, and the Wisconsin Card Sorting Test (WCST), which is associated with functioning of the dorsolateral prefrontal cortex, were administered to 22 children with OCD and 22 healthy controls matched for gender, age, and intelligence. RESULTS: OCD patients displayed poor performance on the IGT. In contrast, performance on the WCST was not impaired in OCD patients compared to controls. CONCLUSIONS: These findings are in line with previous studies demonstrating that OCD in childhood is associated with a dysfunction of orbitofrontal-striatal-thalamic circuitry. BioMed Central 2012-10-12 /pmc/articles/PMC3508952/ /pubmed/23062199 http://dx.doi.org/10.1186/1744-859X-11-25 Text en Copyright ©2012 Kodaira et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Primary Research
Kodaira, Masaki
Iwadare, Yoshitaka
Ushijima, Hirokage
Oiji, Arata
Kato, Motoichiro
Sugiyama, Nobuhiro
Sasayama, Daimei
Usami, Masahide
Watanabe, Kyota
Saito, Kazuhiko
Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
title Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
title_full Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
title_fullStr Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
title_full_unstemmed Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
title_short Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder
title_sort poor performance on the iowa gambling task in children with obsessive-compulsive disorder
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508952/
https://www.ncbi.nlm.nih.gov/pubmed/23062199
http://dx.doi.org/10.1186/1744-859X-11-25
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