Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction

Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS, but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultur...

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Detalles Bibliográficos
Autores principales: Kim, Sung Hoon, Youn, Jeehee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2012
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509167/
https://www.ncbi.nlm.nih.gov/pubmed/23213316
http://dx.doi.org/10.4110/in.2012.12.5.217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509167/
https://www.ncbi.nlm.nih.gov/pubmed/23213316
http://dx.doi.org/10.4110/in.2012.12.5.217

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