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Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity

This study evaluated the oxidative stress through enzymatic and nonenzymatic biomarkers in diabetic patients with and without hypertension and prediabetics. The SOD and CAT (in erythrocytes) and GPx (in plasma) enzymatic activities, plasma levels of lipid peroxidation, and total thiols were measured...

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Autores principales: Bandeira, Suziy de M., Guedes, Glaucevane da S., da Fonseca, Lucas José S., Pires, André S., Gelain, Daniel P., Moreira, José Claudio F., Rabelo, Luíza A., Vasconcelos, Sandra Mary L., Goulart, Marília Oliveira F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509371/
https://www.ncbi.nlm.nih.gov/pubmed/23259029
http://dx.doi.org/10.1155/2012/819310
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author Bandeira, Suziy de M.
Guedes, Glaucevane da S.
da Fonseca, Lucas José S.
Pires, André S.
Gelain, Daniel P.
Moreira, José Claudio F.
Rabelo, Luíza A.
Vasconcelos, Sandra Mary L.
Goulart, Marília Oliveira F.
author_facet Bandeira, Suziy de M.
Guedes, Glaucevane da S.
da Fonseca, Lucas José S.
Pires, André S.
Gelain, Daniel P.
Moreira, José Claudio F.
Rabelo, Luíza A.
Vasconcelos, Sandra Mary L.
Goulart, Marília Oliveira F.
author_sort Bandeira, Suziy de M.
collection PubMed
description This study evaluated the oxidative stress through enzymatic and nonenzymatic biomarkers in diabetic patients with and without hypertension and prediabetics. The SOD and CAT (in erythrocytes) and GPx (in plasma) enzymatic activities, plasma levels of lipid peroxidation, and total thiols were measured in the blood of 55 subjects with type 2 diabetes and 38 subjects without diabetes (9 pre-diabetics and 29 controls) aged 40–86 years. The total SOD activity and the lipid peroxidation were higher in diabetics compared to nondiabetics. In stratified groups, the total SOD activity was different for the hypertensive diabetics compared to the prediabetics and normotensive controls. Lipid peroxidation was significantly higher in both groups of diabetics (hypertensive and normotensive) compared to prediabetic groups and hypertensive and normotensive controls. There was no significant difference in the CAT and GPx activities, as well as in the concentration of total thiols in the groups studied. Present data strongly suggest the involvement of oxidative stress in the pathophysiology of diabetes, revealing that the increased lipid peroxidation has a close relationship with high glucose levels, as observed by the fasting glucose and HbA1c levels. The results evidence the correlation between lipid peroxidation and DM, irrespective of the presence of hypertension.
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spelling pubmed-35093712012-12-20 Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity Bandeira, Suziy de M. Guedes, Glaucevane da S. da Fonseca, Lucas José S. Pires, André S. Gelain, Daniel P. Moreira, José Claudio F. Rabelo, Luíza A. Vasconcelos, Sandra Mary L. Goulart, Marília Oliveira F. Oxid Med Cell Longev Clinical Study This study evaluated the oxidative stress through enzymatic and nonenzymatic biomarkers in diabetic patients with and without hypertension and prediabetics. The SOD and CAT (in erythrocytes) and GPx (in plasma) enzymatic activities, plasma levels of lipid peroxidation, and total thiols were measured in the blood of 55 subjects with type 2 diabetes and 38 subjects without diabetes (9 pre-diabetics and 29 controls) aged 40–86 years. The total SOD activity and the lipid peroxidation were higher in diabetics compared to nondiabetics. In stratified groups, the total SOD activity was different for the hypertensive diabetics compared to the prediabetics and normotensive controls. Lipid peroxidation was significantly higher in both groups of diabetics (hypertensive and normotensive) compared to prediabetic groups and hypertensive and normotensive controls. There was no significant difference in the CAT and GPx activities, as well as in the concentration of total thiols in the groups studied. Present data strongly suggest the involvement of oxidative stress in the pathophysiology of diabetes, revealing that the increased lipid peroxidation has a close relationship with high glucose levels, as observed by the fasting glucose and HbA1c levels. The results evidence the correlation between lipid peroxidation and DM, irrespective of the presence of hypertension. Hindawi Publishing Corporation 2012 2012-11-08 /pmc/articles/PMC3509371/ /pubmed/23259029 http://dx.doi.org/10.1155/2012/819310 Text en Copyright © 2012 Suziy de M. Bandeira et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Bandeira, Suziy de M.
Guedes, Glaucevane da S.
da Fonseca, Lucas José S.
Pires, André S.
Gelain, Daniel P.
Moreira, José Claudio F.
Rabelo, Luíza A.
Vasconcelos, Sandra Mary L.
Goulart, Marília Oliveira F.
Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
title Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
title_full Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
title_fullStr Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
title_full_unstemmed Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
title_short Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
title_sort characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and sod activity
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509371/
https://www.ncbi.nlm.nih.gov/pubmed/23259029
http://dx.doi.org/10.1155/2012/819310
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