Integrated Bioinformatic and Targeted Deletion Analyses of the SRS Gene Superfamily Identify SRS29C as a Negative Regulator of Toxoplasma Virulence

The Toxoplasma gondii SRS gene superfamily is structurally related to SRS29B (formerly SAG1), a surface adhesin that binds host cells and stimulates host immunity. Comparative genomic analyses of three Toxoplasma strains identified 182 SRS genes distributed across 14 chromosomes at 57 genomic loci....

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Detalles Bibliográficos
Autores principales: Wasmuth, James D., Pszenny, Viviana, Haile, Simon, Jansen, Emily M., Gast, Alexandra T., Sher, Alan, Boyle, Jon P., Boulanger, Martin J., Parkinson, John, Grigg, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509429/
https://www.ncbi.nlm.nih.gov/pubmed/23149485
http://dx.doi.org/10.1128/mBio.00321-12

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