Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo

Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare disorder characterized by segmental accelerated aging and early death from coronary artery disease or stroke. Nearly 90% of HGPS sufferers carry a G608G mutation within exon 11 of LMNA, producing a truncated form of prelamin A, refer...

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Detalles Bibliográficos
Autores principales: Wenzel, Vera, Roedl, Daniela, Gabriel, Diana, Gordon, Leslie B., Herlyn, Meenhard, Schneider, Reinhard, Ring, Johannes, Djabali, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509444/
https://www.ncbi.nlm.nih.gov/pubmed/23213444
http://dx.doi.org/10.1242/bio.20121149

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