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Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes

Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed...

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Autores principales: West, Christina E., Dunstan, Janet, McCarthy, Suzi, Metcalfe, Jessica, D’Vaz, Nina, Meldrum, Suzanne, Oddy, Wendy H., Tulic, Meri K., Prescott, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509518/
https://www.ncbi.nlm.nih.gov/pubmed/23201845
http://dx.doi.org/10.3390/nu4111747
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author West, Christina E.
Dunstan, Janet
McCarthy, Suzi
Metcalfe, Jessica
D’Vaz, Nina
Meldrum, Suzanne
Oddy, Wendy H.
Tulic, Meri K.
Prescott, Susan L.
author_facet West, Christina E.
Dunstan, Janet
McCarthy, Suzi
Metcalfe, Jessica
D’Vaz, Nina
Meldrum, Suzanne
Oddy, Wendy H.
Tulic, Meri K.
Prescott, Susan L.
author_sort West, Christina E.
collection PubMed
description Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes.
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spelling pubmed-35095182012-12-18 Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes West, Christina E. Dunstan, Janet McCarthy, Suzi Metcalfe, Jessica D’Vaz, Nina Meldrum, Suzanne Oddy, Wendy H. Tulic, Meri K. Prescott, Susan L. Nutrients Article Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes. MDPI 2012-11-14 /pmc/articles/PMC3509518/ /pubmed/23201845 http://dx.doi.org/10.3390/nu4111747 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
West, Christina E.
Dunstan, Janet
McCarthy, Suzi
Metcalfe, Jessica
D’Vaz, Nina
Meldrum, Suzanne
Oddy, Wendy H.
Tulic, Meri K.
Prescott, Susan L.
Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
title Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
title_full Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
title_fullStr Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
title_full_unstemmed Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
title_short Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
title_sort associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509518/
https://www.ncbi.nlm.nih.gov/pubmed/23201845
http://dx.doi.org/10.3390/nu4111747
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